{"id":"W4307033179","doi":"10.1007/s13555-022-00822-x","title":"Dupilumab Treatment in Adults with Moderate-to-Severe Atopic Dermatitis is Efficacious Regardless of Age of Disease Onset: a Post Hoc Analysis of Two Phase 3 Clinical Trials","year":2022,"lang":"en","type":"article","venue":"Dermatology and Therapy","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research","funders":"LEO Pharma; Galderma; Incyte; Regeneron Pharmaceuticals; Sanofi; GlaxoSmithKline; Pfizer; Kiniksa Pharmaceuticals; AstraZeneca; Eli Lilly and Company","keywords":"Eczema Area and Severity Index; Atopic dermatitis; Dupilumab; Medicine; Placebo; Age of onset; Post-hoc analysis; Young adult; Severity of illness; Internal medicine; Clinical trial; Disease; Pediatrics; Dermatology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000315535,0.0002095198,0.001976955,0.0005213322,0.00007477831,0.000003047421,0.0001115505,0.00009511896,0.0002193697],"category_scores_gemma":[0.0000945222,0.0001585571,0.0003583425,0.0005211043,0.000312838,0.00003553026,0.0000357639,0.0001412679,9.340511e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001926439,"about_ca_system_score_gemma":0.0002354578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009546435,"about_ca_topic_score_gemma":0.0000943655,"domain_scores_codex":[0.9969288,0.00121294,0.00112587,0.0003381142,0.0001891266,0.0002051369],"domain_scores_gemma":[0.9981087,0.0007379997,0.0004251034,0.0004302215,0.00009998054,0.0001979568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.07512376,0.006785987,0.8933512,0.0002754761,0.005271035,0.002640821,0.004672355,0.0001708622,0.00005291522,0.0002889779,0.0003890028,0.01097759],"study_design_scores_gemma":[0.1408074,0.005535314,0.8371902,0.0003262034,0.005208802,0.001036531,0.001595022,0.003281901,0.002885403,0.00042608,0.001180077,0.0005270014],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924756,0.004418239,0.00004523445,0.001455489,0.00004093507,0.0008393497,0.0006530549,0.0000139206,0.00005819298],"genre_scores_gemma":[0.9967101,0.001315604,0.00007134265,0.001399849,0.000006410872,0.0001360279,0.0003173578,0.00001364251,0.00002961688],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06568369,"threshold_uncertainty_score":0.6465769,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03702511574311008,"score_gpt":0.3742092569094753,"score_spread":0.3371841411663652,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}