{"id":"W4307033179","doi":"10.1007/s13555-022-00822-x","title":"Dupilumab Treatment in Adults with Moderate-to-Severe Atopic Dermatitis is Efficacious Regardless of Age of Disease Onset: a Post Hoc Analysis of Two Phase 3 Clinical Trials","year":2022,"lang":"en","type":"article","venue":"Dermatology and Therapy","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research","funders":"LEO Pharma; Galderma; Incyte; Regeneron Pharmaceuticals; Sanofi; GlaxoSmithKline; Pfizer; Kiniksa Pharmaceuticals; AstraZeneca; Eli Lilly and Company","keywords":"Eczema Area and Severity Index; Atopic dermatitis; Dupilumab; Medicine; Placebo; Age of onset; Post-hoc analysis; Young adult; Severity of illness; Internal medicine; Clinical trial; Disease; Pediatrics; Dermatology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01036171,0.00180299,0.005862767,0.000614385,0.0005340816,0.001979855,0.0008088555,0.001421339,0.00364601],"category_scores_gemma":[0.007227339,0.0007169239,0.01127554,0.0007707755,0.0008309357,0.001657333,0.0006702116,0.002380223,0.0004666518],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008825866,"about_ca_system_score_gemma":0.001188272,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007200921,"about_ca_topic_score_gemma":0.002653082,"domain_scores_codex":[0.9938374,0.003923364,0.000618606,0.0007078551,0.0004681383,0.0004447607],"domain_scores_gemma":[0.9941916,0.003075462,0.001371205,0.0004401733,0.0004251788,0.00049636],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.9388137,0.001436749,0.004197817,0.001995001,0.03075921,0.00007647604,0.0001016114,0.0004809139,0.00282517,0.00007562999,0.0009028607,0.01833474],"study_design_scores_gemma":[0.7416677,0.1373101,0.04985204,0.0004153615,0.06279015,0.0003008233,0.0001422638,0.00172316,0.001861791,0.0003674274,0.003457814,0.0001112371],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9465418,0.0407461,0.001492229,0.0006980975,0.0005472406,0.00367194,0.003133057,0.0001544881,0.003015104],"genre_scores_gemma":[0.987598,0.005427967,0.001457985,0.0007534606,0.0003819146,0.001775945,0.001627481,0.00004113498,0.0009360783],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01036171,"threshold_uncertainty_score":0.05479866,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03702511574311008,"score_gpt":0.3742092569094753,"score_spread":0.3371841411663652,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}