{"id":"W4307042101","doi":"10.1002/1873-3468.14523","title":"Structural biology of <scp>DOCK‐family</scp> guanine nucleotide exchange factors","year":2022,"lang":"en","type":"review","venue":"FEBS Letters","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"Medical Research Council; Canadian Institutes of Health Research; National Science Foundation; Cancer Research UK; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; UK Research and Innovation","keywords":"DOCK; Guanine nucleotide exchange factor; GTPase; CDC42; Biology; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001913328,0.0004913116,0.0009829984,0.0002002219,0.0001190735,0.00001774066,0.0004740486,0.0003257787,0.0002225609],"category_scores_gemma":[0.0001569617,0.0004283012,0.0006287919,0.0002310561,0.0001398958,0.000004154479,0.0003546022,0.0003079174,0.000008888006],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005416617,"about_ca_system_score_gemma":0.0001022636,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000402309,"about_ca_topic_score_gemma":0.000003613316,"domain_scores_codex":[0.997896,0.0003152787,0.0005805339,0.0006091398,0.0001880952,0.0004109169],"domain_scores_gemma":[0.9986609,0.00007755393,0.0005658419,0.0005622203,0.00003075837,0.0001027615],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002827072,0.0001147098,0.0003445517,0.01841463,0.002024537,0.00009081955,0.0003473048,0.0001237734,0.2581898,0.0004659095,0.03781709,0.6820386],"study_design_scores_gemma":[0.0001947486,0.0001080617,0.0000316175,0.0002935594,0.000169769,0.00001585884,0.00002803165,0.000003443466,0.00240194,0.000007763116,0.9965526,0.0001926024],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.03754621,0.9606115,0.0001289835,0.00002630077,0.0004751165,0.0005639684,0.0003713369,0.00002863473,0.0002479482],"genre_scores_gemma":[0.001770303,0.9920424,0.0002698209,0.0005598216,0.0005307176,0.0000855176,0.004381826,0.0001081298,0.0002514557],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9587355,"threshold_uncertainty_score":0.9998169,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04045806092508475,"score_gpt":0.2883720017307471,"score_spread":0.2479139408056624,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}