{"id":"W4307055586","doi":"10.1093/pch/pxac100.091","title":"92 Confirmatory genetic testing for all CF screen positive newborns: a 12-year analysis","year":2022,"lang":"en","type":"article","venue":"Paediatrics & Child Health","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre","funders":"","keywords":"Medicine; Sweat test; Cystic fibrosis; Genetic testing; Newborn screening; Genetic counseling; Mutation; Asymptomatic; Carrier testing; Internal medicine; Pediatrics; Mutation testing; Gastroenterology; Genetics; Prenatal diagnosis; Gene; Biology; Pregnancy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009386914,0.0004036483,0.0004042874,0.002246449,0.0007074273,0.0007389277,0.0005298377,0.0006741558,0.001698426],"category_scores_gemma":[0.003562275,0.0004691884,0.0006691802,0.001805376,0.000349894,0.0005502145,0.0006338469,0.0006551323,0.0004397266],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006422483,"about_ca_system_score_gemma":0.0006163362,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01142458,"about_ca_topic_score_gemma":0.007647792,"domain_scores_codex":[0.9986235,0.0002649878,0.0001833893,0.0003386248,0.0003626194,0.0002268723],"domain_scores_gemma":[0.9972319,0.0006354391,0.001102161,0.0001857762,0.000414193,0.0004305952],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00006911559,0.00003557202,0.9977888,0.000005914987,0.00001535529,0.0008470008,0.00005949835,0.00002172762,0.0001082655,0.000009286926,0.00009017115,0.0009493303],"study_design_scores_gemma":[0.000009521889,0.0002140707,0.9955954,0.00001553023,0.00003012342,0.003031627,0.0003992399,0.0002556126,0.00008850802,0.00001015815,0.0003427699,0.000007361688],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985984,0.0002534566,0.0001083797,0.0000383278,0.000004171951,0.00002401257,0.0005811777,0.000004818249,0.0003872909],"genre_scores_gemma":[0.9986296,0.0002150348,0.0001432404,0.00005357771,0.00001044536,0.00002217893,0.000779665,0.000004180258,0.0001419743],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01142458,"threshold_uncertainty_score":0.02271616,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02641337900606909,"score_gpt":0.3260106133135816,"score_spread":0.2995972343075124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}