{"id":"W4307069447","doi":"10.1002/em.22514","title":"Impact of sampling time on the detection of mutations in rapidly proliferating tissues using transgenic rodent gene mutation models: A review","year":2022,"lang":"en","type":"review","venue":"Environmental and Molecular Mutagenesis","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Environment and Climate Change Canada; University of Ottawa; Health Canada","funders":"Health Canada; U.S. Food and Drug Administration; Environment and Climate Change Canada","keywords":"Somatic cell; Biology; Transgene; Mutation; Gene; Germ cell; Germline mutation; Concordance; Andrology; Genetics; Bioinformatics; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005959292,0.001080666,0.002919166,0.005367813,0.0003151712,0.001642501,0.001809282,0.001757629,0.002296397],"category_scores_gemma":[0.01180778,0.0007068581,0.002529437,0.003777154,0.0009784279,0.001699799,0.0007209778,0.001260103,0.0007807476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001111605,"about_ca_system_score_gemma":0.003509063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002959238,"about_ca_topic_score_gemma":0.004217871,"domain_scores_codex":[0.9971915,0.0007666968,0.0007835129,0.0004355465,0.0007470502,0.00007575185],"domain_scores_gemma":[0.9749811,0.02001031,0.002062694,0.000320609,0.002479475,0.0001458367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000200686,0.00007915479,0.0009173788,0.213124,0.0007455751,0.0001534331,0.0002239424,0.0005901414,0.003625994,0.002079384,0.007497188,0.7707632],"study_design_scores_gemma":[0.00006338667,0.001017956,0.006242243,0.1320827,0.007399904,0.001944229,0.000405121,0.0004182631,0.007902439,0.003056361,0.839316,0.0001514194],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003158906,0.9985768,0.0003467921,0.0001599228,0.00006174976,0.00002120204,0.00007433363,0.000008539197,0.0004348043],"genre_scores_gemma":[0.001851975,0.9969855,0.0006259443,0.0002184289,0.00005090971,0.00003573821,0.00008971092,0.000006104404,0.0001356776],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005959292,"threshold_uncertainty_score":0.03151608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04224827318152372,"score_gpt":0.315647758520588,"score_spread":0.2733994853390642,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}