{"id":"W4307091937","doi":"10.1002/hep4.2100","title":"Rencofilstat, a cyclophilin inhibitor: A phase 2a, multicenter, single‐blind, placebo‐controlled study in F2/F3 NASH","year":2022,"lang":"en","type":"article","venue":"Hepatology Communications","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"NAEJA-RGM Pharmaceuticals (Canada)","funders":"","keywords":"Placebo; Medicine; Tolerability; Pharmacokinetics; Internal medicine; Adverse effect; Population; Gastroenterology; Pharmacology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002144199,0.001217728,0.001508297,0.0005915161,0.0004785622,0.0005571343,0.0006075774,0.001304304,0.002220564],"category_scores_gemma":[0.0006771587,0.0004331114,0.0009267901,0.000343547,0.0006846905,0.0005841636,0.0002025854,0.001564285,0.0003713385],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000606573,"about_ca_system_score_gemma":0.001135332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001122926,"about_ca_topic_score_gemma":0.0028484,"domain_scores_codex":[0.9995958,0.0001683052,0.00002422064,0.00008009763,0.00005799799,0.00007357662],"domain_scores_gemma":[0.9995281,0.00008070136,0.0001206395,0.00004041124,0.000052358,0.0001780047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6205079,0.08595017,0.006011731,0.001128441,0.001397762,0.0003641548,0.0002251916,0.001438966,0.1824574,0.0002241039,0.00235933,0.09793492],"study_design_scores_gemma":[0.4354359,0.5222695,0.01928213,0.00004241463,0.0005175179,0.0003879288,0.00004644371,0.001295591,0.01814069,0.0001019271,0.002428458,0.00005152689],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924885,0.002204726,0.0009757281,0.0002417459,0.0000717072,0.002556548,0.0006828982,0.0001459386,0.0006320976],"genre_scores_gemma":[0.9887142,0.001510815,0.003181159,0.0007261624,0.0001411448,0.002445968,0.00135893,0.00004204499,0.001879461],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002220564,"threshold_uncertainty_score":0.01133978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06527210749117053,"score_gpt":0.3656730332756136,"score_spread":0.3004009257844431,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}