{"id":"W4307091937","doi":"10.1002/hep4.2100","title":"Rencofilstat, a cyclophilin inhibitor: A phase 2a, multicenter, single‐blind, placebo‐controlled study in F2/F3 NASH","year":2022,"lang":"en","type":"article","venue":"Hepatology Communications","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"NAEJA-RGM Pharmaceuticals (Canada)","funders":"","keywords":"Placebo; Medicine; Tolerability; Pharmacokinetics; Internal medicine; Adverse effect; Population; Gastroenterology; Pharmacology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004069001,0.0002289499,0.0007065029,0.0003728938,0.0004812291,0.00001890872,0.0005118923,0.00006273365,0.0002994581],"category_scores_gemma":[0.000199036,0.0002214025,0.0001923349,0.0004319947,0.0001574705,0.00007003766,0.0007391983,0.0005229877,0.00005010145],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005247577,"about_ca_system_score_gemma":0.0002575426,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004398548,"about_ca_topic_score_gemma":0.002005275,"domain_scores_codex":[0.9971609,0.001158011,0.0006879064,0.0003924138,0.0002663647,0.0003344108],"domain_scores_gemma":[0.9968064,0.0007587299,0.000204272,0.001958464,0.0000971263,0.0001750343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.01372838,0.1061233,0.8674414,0.00002458261,0.0009474516,0.0006355465,0.005093173,0.00001956354,0.0002880022,0.0004686672,0.002516194,0.002713742],"study_design_scores_gemma":[0.8201466,0.01014932,0.08534306,0.0001800798,0.003768962,0.0003202819,0.02128024,0.01778268,0.000217436,0.000440779,0.03930165,0.001068959],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843942,0.003219086,0.000004182753,0.006456249,0.0001553737,0.003808195,0.0001375074,0.00009832711,0.001726859],"genre_scores_gemma":[0.9920436,0.0003840784,0.0005196319,0.000737238,0.00002270543,0.005628841,0.0004868026,0.00002998786,0.0001470986],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8064182,"threshold_uncertainty_score":0.9028531,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06527210749117053,"score_gpt":0.3656730332756136,"score_spread":0.3004009257844431,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}