{"id":"W4307114719","doi":"10.1038/s41375-022-01711-0","title":"Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes","year":2022,"lang":"en","type":"article","venue":"Leukemia","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Simon Fraser University; BC Cancer Agency","funders":"Cilag; Division of Cancer Epidemiology and Genetics, National Cancer Institute; Medical Research Council; Celgene; Janssen Pharmaceuticals; Gilead Sciences; Servier; Amgen; Pfizer; GlaxoSmithKline; World Health Organization; National Cancer Institute; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Genome-wide association study; Biology; Heritability; Genetics; Genetic association; Genetic architecture; Germline; Missing heritability problem; Locus (genetics); Quantitative trait locus; Single-nucleotide polymorphism; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000240011,0.0002270017,0.0004331926,0.00007463062,0.000343881,0.00003261163,0.0001627025,0.00006343286,0.0004997333],"category_scores_gemma":[0.00006202726,0.0001960759,0.0002375196,0.0001812009,0.00007180991,0.00003767173,0.0001609487,0.00007887759,0.00004750042],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001808454,"about_ca_system_score_gemma":0.0004366442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000742781,"about_ca_topic_score_gemma":0.0002286692,"domain_scores_codex":[0.9983293,0.00006643967,0.00039826,0.0005027848,0.0003402535,0.0003628962],"domain_scores_gemma":[0.9988558,0.00019498,0.0001321436,0.0005996614,0.00007073708,0.0001466454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001262759,0.00160497,0.8800246,0.0003765531,0.0002781791,0.0003269799,0.000424874,0.00005379474,0.003781955,0.000261436,0.02391058,0.08769335],"study_design_scores_gemma":[0.006431371,0.0008657546,0.9677108,0.00003120916,0.0002699402,0.00009619749,0.0001220298,0.001610824,0.009985226,0.0004261962,0.01223158,0.0002188686],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960847,0.0005639624,0.00007262684,0.0004339229,0.0003586128,0.001385542,0.0002084144,0.00009840207,0.0007938295],"genre_scores_gemma":[0.9947323,0.00001494326,0.001016224,0.0003809766,0.0002279487,0.001224523,0.0005472072,0.00004151507,0.001814403],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08768623,"threshold_uncertainty_score":0.7995744,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.015973320079582,"score_gpt":0.2779399029163564,"score_spread":0.2619665828367744,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}