{"id":"W4307114719","doi":"10.1038/s41375-022-01711-0","title":"Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes","year":2022,"lang":"en","type":"article","venue":"Leukemia","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Simon Fraser University; BC Cancer Agency","funders":"Cilag; Division of Cancer Epidemiology and Genetics, National Cancer Institute; Medical Research Council; Celgene; Janssen Pharmaceuticals; Gilead Sciences; Servier; Amgen; Pfizer; GlaxoSmithKline; World Health Organization; National Cancer Institute; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Genome-wide association study; Biology; Heritability; Genetics; Genetic association; Genetic architecture; Germline; Missing heritability problem; Locus (genetics); Quantitative trait locus; Single-nucleotide polymorphism; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002603244,0.00020274,0.0002479607,0.00156556,0.0002978301,0.0006710066,0.0002914543,0.0003105901,0.003140544],"category_scores_gemma":[0.00127198,0.0001155763,0.0002681976,0.0008353032,0.0002981713,0.000281969,0.0005236724,0.0003215772,0.0002562521],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002918538,"about_ca_system_score_gemma":0.0002508369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00108774,"about_ca_topic_score_gemma":0.001879669,"domain_scores_codex":[0.9996365,0.00004979596,0.00003216574,0.00008580419,0.00008309649,0.0001125773],"domain_scores_gemma":[0.9994944,0.0001376712,0.0001927375,0.00004216489,0.00005925056,0.00007369675],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000791912,0.00006090552,0.9341917,0.0000350267,0.0001447959,0.001963003,0.000303812,0.000208023,0.04226813,0.0008098184,0.0003538736,0.01886904],"study_design_scores_gemma":[0.00003992382,0.0001561315,0.9830618,0.00002498965,0.0001536618,0.008469273,0.0006329922,0.0006344387,0.003976368,0.001092736,0.001746356,0.00001136098],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982706,0.0002676516,0.0001851747,0.00005283961,0.000005003706,0.000006055448,0.0001682899,0.000008365585,0.001036023],"genre_scores_gemma":[0.9992924,0.00009156632,0.000138801,0.00002787921,0.000006796586,0.000002895289,0.0002117126,0.000006085138,0.0002219413],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003140544,"threshold_uncertainty_score":0.01050615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.015973320079582,"score_gpt":0.2779399029163564,"score_spread":0.2619665828367744,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}