{"id":"W4307178391","doi":"10.1161/hypertensionaha.122.19300","title":"Right Ventricular Maladaptation to Pressure Overload in Fischer Rats Is Associated With Profound Deficiency in Adenylate Kinase 1 and Impaired Ventricular Energetics","year":2022,"lang":"en","type":"article","venue":"Hypertension","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec; Ontario Genomics; University of Ottawa; Canadian Electricity Association; Yorkville University","funders":"Canadian Institutes of Health Research","keywords":"Internal medicine; Ventricle; Endocrinology; Hypoxia (environmental); Adenylate kinase; Oxidative phosphorylation; Ventricular pressure; Pulmonary hypertension; Pressure overload; Mitochondrion; Oxidative stress; Medicine; Biology; Heart failure; Chemistry; Blood pressure; Receptor; Oxygen; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001872267,0.0001341706,0.0001666287,0.000119339,0.0001000337,0.00001369431,0.00006910666,0.0001176797,0.00006120651],"category_scores_gemma":[0.00008736603,0.0001182008,0.00003255799,0.0003370371,0.00001891143,0.000005792613,0.0001023572,0.0001345332,0.000002754357],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002962484,"about_ca_system_score_gemma":0.00004431988,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004939759,"about_ca_topic_score_gemma":0.00008889464,"domain_scores_codex":[0.9988292,0.0001868845,0.0001824809,0.0003927486,0.0001828233,0.0002258594],"domain_scores_gemma":[0.9996216,0.0000119423,0.00006499402,0.0001762299,0.00006150914,0.00006377291],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009283987,0.0007191388,0.04387346,0.0000311941,0.00005183765,0.002501473,0.0004596343,0.01062411,0.9325492,0.00005428583,0.007836526,0.0003707099],"study_design_scores_gemma":[0.01636761,0.007689834,0.2818578,0.0002751951,0.0004130775,0.00196593,0.001062068,0.02122298,0.2813208,0.0001840545,0.3852148,0.002425815],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972426,0.001658168,0.0001122505,0.0003394195,0.0001759779,0.0003852873,0.00001865287,0.000009011635,0.00005858501],"genre_scores_gemma":[0.9980733,0.00003536333,0.0001630067,0.000898154,0.00003129165,0.0000646663,0.0001653984,0.00001625637,0.0005525821],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6512284,"threshold_uncertainty_score":0.4820087,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01094348121322881,"score_gpt":0.207444700449552,"score_spread":0.1965012192363232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}