{"id":"W4307178391","doi":"10.1161/hypertensionaha.122.19300","title":"Right Ventricular Maladaptation to Pressure Overload in Fischer Rats Is Associated With Profound Deficiency in Adenylate Kinase 1 and Impaired Ventricular Energetics","year":2022,"lang":"en","type":"article","venue":"Hypertension","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec; Ontario Genomics; University of Ottawa; Canadian Electricity Association; Yorkville University","funders":"Canadian Institutes of Health Research","keywords":"Internal medicine; Ventricle; Endocrinology; Hypoxia (environmental); Adenylate kinase; Oxidative phosphorylation; Ventricular pressure; Pulmonary hypertension; Pressure overload; Mitochondrion; Oxidative stress; Medicine; Biology; Heart failure; Chemistry; Blood pressure; Receptor; Oxygen; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002038232,0.0008007059,0.0004061694,0.0005890642,0.0002151879,0.0002016338,0.0002061021,0.000331381,0.001926697],"category_scores_gemma":[0.0001844262,0.0003246072,0.0003650039,0.0001332831,0.0005797123,0.0002958584,0.0003481864,0.0008679831,0.0002487798],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000293546,"about_ca_system_score_gemma":0.0002404197,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007179203,"about_ca_topic_score_gemma":0.001156037,"domain_scores_codex":[0.9998273,0.00001503863,0.00001299677,0.00004808747,0.00003590518,0.00006070768],"domain_scores_gemma":[0.9996081,0.00002568432,0.0001539104,0.00003751087,0.00002059273,0.0001541716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009201947,0.00008848686,0.002105569,0.00001988325,0.00001181004,0.000162885,0.00002670759,0.00004590673,0.9956005,0.00005131386,0.00004540987,0.0009214236],"study_design_scores_gemma":[0.0002104836,0.006255296,0.2398576,0.0000256202,0.0001367421,0.003160203,0.0003922339,0.002202077,0.7460189,0.0003159569,0.001373668,0.00005103505],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989598,0.0001266822,0.0005568562,0.00005285315,0.000009858474,0.000005718727,0.0001363001,0.00002878628,0.0001230903],"genre_scores_gemma":[0.997631,0.0001659785,0.0007998598,0.00005566702,0.00001261645,0.00003035576,0.0002972144,0.00001971207,0.0009875481],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001926697,"threshold_uncertainty_score":0.006445408,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01094348121322881,"score_gpt":0.207444700449552,"score_spread":0.1965012192363232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}