{"id":"W4307181158","doi":"10.15252/emmm.202115343","title":"Lactate dehydrogenases promote glioblastoma growth and invasion via a metabolic symbiosis","year":2022,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institut National Du Cancer; Ligue Contre le Cancer; Institut National de la Santé et de la Recherche Médicale; Fondation ARC pour la Recherche sur le Cancer; Agence Nationale de la Recherche; CNIB","keywords":"Glioblastoma; Symbiosis; Biology; Metabolic pathway; Computational biology; Biochemistry; Cancer research; Cell biology; Metabolism; Genetics; Bacteria","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003109759,0.0002815458,0.0003769471,0.0001514771,0.0002318141,0.00001275908,0.0002416486,0.00008165957,0.0001125738],"category_scores_gemma":[0.0001469999,0.000258789,0.0001103747,0.0003117661,0.0001687273,0.000006065181,0.0003690994,0.0001937103,0.000003544091],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001217719,"about_ca_system_score_gemma":0.00007939012,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001280194,"about_ca_topic_score_gemma":0.00002046449,"domain_scores_codex":[0.9981436,0.0001818544,0.0002933826,0.0005975988,0.0004057268,0.0003779077],"domain_scores_gemma":[0.9991348,0.00001109591,0.0001268057,0.0004299265,0.00006557532,0.0002317931],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000157122,0.00006708926,0.0001090471,0.00003365845,0.0001239238,0.00003269227,0.0001941089,0.000008940544,0.9919133,0.0001999641,0.001705447,0.005454724],"study_design_scores_gemma":[0.002030114,0.001052686,0.0005350086,0.0000234798,0.0002226355,0.0004018383,0.0001481549,0.00006309525,0.8073244,0.0003412458,0.1874995,0.0003578122],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9575186,0.03892607,0.0008588683,0.001009861,0.0007051859,0.0003903288,0.00002622541,0.00003641122,0.0005284753],"genre_scores_gemma":[0.9939464,0.002122244,0.000239492,0.002435101,0.0007407845,0.0001351793,0.0001225974,0.00005897368,0.0001991723],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1857941,"threshold_uncertainty_score":0.9999864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005994858044040843,"score_gpt":0.2251293172515577,"score_spread":0.2191344592075168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}