{"id":"W4307211509","doi":"10.1172/jci.insight.162207","title":"GATOR2-dependent mTORC1 activity is a therapeutic vulnerability in FOXO1 fusion–positive rhabdomyosarcoma","year":2022,"lang":"en","type":"article","venue":"JCI Insight","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pediatric Oncology Group","funders":"University of California, San Francisco; National Institutes of Health; National Cancer Institute; Frank A. Campini Foundation; American Association for Cancer Research","keywords":"mTORC1; Fusion gene; Cancer research; FOXO1; Alveolar rhabdomyosarcoma; Biology; PAX3; Rhabdomyosarcoma; Gene; Computational biology; Genetics; Medicine; PI3K/AKT/mTOR pathway; Signal transduction; Transcription factor; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002246865,0.0001777112,0.0001696713,0.00006592256,0.0001556151,0.00001753199,0.0002073038,0.00008830537,0.0002527743],"category_scores_gemma":[0.00002050233,0.0001822338,0.0001021029,0.0001558552,0.00003638691,0.000004219499,0.0003281803,0.0002694642,0.000006375202],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008468489,"about_ca_system_score_gemma":0.00007220994,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008650801,"about_ca_topic_score_gemma":0.00009377189,"domain_scores_codex":[0.9987129,0.0001547415,0.0001774045,0.0004500933,0.0002291102,0.0002757776],"domain_scores_gemma":[0.9993985,0.00002395829,0.00004585843,0.0004267174,0.00003196788,0.00007300871],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002258683,0.0004221454,0.009337774,0.00002048083,0.00005568285,0.00002449708,0.001030071,0.001051481,0.9760693,0.00007531943,0.0004946164,0.01119272],"study_design_scores_gemma":[0.001280796,0.0006452928,0.06409185,0.000008847925,0.00002221343,0.00003999363,0.0002694729,0.0006238078,0.8679641,0.0002366917,0.06432123,0.0004957166],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935892,0.001220014,0.002732452,0.0003057331,0.0002480998,0.0002888134,0.0000448247,0.00001823344,0.001552641],"genre_scores_gemma":[0.9986482,0.00005798181,0.00007126179,0.0005045305,0.0001057718,0.0001115154,0.00002958231,0.00002478765,0.0004463577],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1081053,"threshold_uncertainty_score":0.743128,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01076318049151628,"score_gpt":0.2921405895217569,"score_spread":0.2813774090302406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}