{"id":"W4307211509","doi":"10.1172/jci.insight.162207","title":"GATOR2-dependent mTORC1 activity is a therapeutic vulnerability in FOXO1 fusion–positive rhabdomyosarcoma","year":2022,"lang":"en","type":"article","venue":"JCI Insight","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pediatric Oncology Group","funders":"University of California, San Francisco; National Institutes of Health; National Cancer Institute; Frank A. Campini Foundation; American Association for Cancer Research","keywords":"mTORC1; Fusion gene; Cancer research; FOXO1; Alveolar rhabdomyosarcoma; Biology; PAX3; Rhabdomyosarcoma; Gene; Computational biology; Genetics; Medicine; PI3K/AKT/mTOR pathway; Signal transduction; Transcription factor; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001275318,0.0003435156,0.0002229461,0.000243785,0.0001736261,0.0002817581,0.0001708034,0.0002856821,0.001962301],"category_scores_gemma":[0.00007477995,0.0001286891,0.0001724512,0.0001380211,0.0002826877,0.0001315246,0.0002432989,0.0004848946,0.0003603878],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003313585,"about_ca_system_score_gemma":0.0002385187,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005974956,"about_ca_topic_score_gemma":0.001547407,"domain_scores_codex":[0.9998744,0.00001465863,0.00001163869,0.00002423594,0.00004769121,0.00002739057],"domain_scores_gemma":[0.999938,0.000009971737,0.00002430516,0.000006649138,0.000004344232,0.00001678417],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006202679,0.00001423413,0.0002552294,0.00002183448,0.000004328147,0.0001558265,0.000007527689,0.0001325735,0.9979025,0.0003063659,0.00008264211,0.001054908],"study_design_scores_gemma":[0.0000206032,0.0001558771,0.006373457,0.000009626964,0.00002034137,0.001841202,0.00003777371,0.001610538,0.9842147,0.0001566598,0.005551815,0.000007303881],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880881,0.0006007748,0.004788021,0.0002265508,0.00002657732,0.00003841105,0.000973045,0.0002613384,0.004997043],"genre_scores_gemma":[0.9950303,0.0003524194,0.001522042,0.00006016297,0.000004055619,0.00001979098,0.0004500782,0.00004170472,0.002519417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001962301,"threshold_uncertainty_score":0.006564558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01076318049151628,"score_gpt":0.2921405895217569,"score_spread":0.2813774090302406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}