{"id":"W4307238508","doi":"10.3390/biomedinformatics2040035","title":"Omicron SARS-CoV-2 Spike-1 Protein’s Decreased Binding Affinity to α7nAChr: Implications for Autonomic Dysregulation of the Parasympathetic Nervous System and the Cholinergic Anti-Inflammatory Pathway—An In Silico Analysis","year":2022,"lang":"en","type":"article","venue":"BioMedInformatics","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Cholinergic; In silico; Biology; Docking (animal); Protein–protein interaction; Neuroscience; Cell biology; Genetics; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001660564,0.00019853,0.0005129561,0.0007427324,0.0003714579,0.00005814797,0.0004328562,0.00008529892,0.00000119164],"category_scores_gemma":[0.0001447489,0.0001322248,0.0002276072,0.001529847,0.0001953845,0.0001415069,0.000235341,0.0002087641,0.000003725321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006199149,"about_ca_system_score_gemma":0.0004502699,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002328679,"about_ca_topic_score_gemma":0.00009458908,"domain_scores_codex":[0.9980345,0.0001476336,0.000866574,0.0002233277,0.000378593,0.0003493937],"domain_scores_gemma":[0.9984566,0.0001788739,0.0003976253,0.0007850128,0.0001265497,0.00005532906],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007768279,0.0003339872,0.05056813,0.001118588,0.0003763307,0.000002319849,0.006480461,0.0007419176,0.9286525,0.006170014,0.00007161182,0.004707279],"study_design_scores_gemma":[0.01149515,0.0007930895,0.1837475,0.0002820755,0.001125431,0.00008761656,0.009616777,0.3604064,0.4245312,0.0002528248,0.006993008,0.0006689007],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952648,0.0000517644,0.0006088547,0.0005307479,0.00006873737,0.003207448,0.0001488594,0.00005308952,0.00006573824],"genre_scores_gemma":[0.9976047,0.000001007764,0.0003447622,0.0009801014,0.00004059901,0.0009524883,0.00004864971,0.00002205641,0.000005610525],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5041213,"threshold_uncertainty_score":0.5391969,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03088518821628682,"score_gpt":0.3085721851082739,"score_spread":0.2776869968919871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}