{"id":"W4307238508","doi":"10.3390/biomedinformatics2040035","title":"Omicron SARS-CoV-2 Spike-1 Protein’s Decreased Binding Affinity to α7nAChr: Implications for Autonomic Dysregulation of the Parasympathetic Nervous System and the Cholinergic Anti-Inflammatory Pathway—An In Silico Analysis","year":2022,"lang":"en","type":"article","venue":"BioMedInformatics","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Cholinergic; In silico; Biology; Docking (animal); Protein–protein interaction; Neuroscience; Cell biology; Genetics; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002774352,0.000972208,0.0009384016,0.000350137,0.0004534532,0.0005622194,0.0006590177,0.0007457663,0.002417405],"category_scores_gemma":[0.0006298504,0.000287583,0.001329669,0.0003280043,0.0002850569,0.0004397237,0.0003560026,0.0005201569,0.0003687455],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004985891,"about_ca_system_score_gemma":0.0006821875,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008396695,"about_ca_topic_score_gemma":0.007491862,"domain_scores_codex":[0.9998357,0.00002917896,0.00001091233,0.00002901753,0.00004581489,0.00004936953],"domain_scores_gemma":[0.9997936,0.00008849024,0.00003933215,0.0000102505,0.00003301984,0.00003531994],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001629393,0.0007582102,0.05849484,0.0008208365,0.0006897419,0.002205503,0.0001717796,0.779532,0.1401499,0.003996726,0.002882618,0.008668514],"study_design_scores_gemma":[0.0001767764,0.0008012342,0.01744061,0.00004222133,0.000253385,0.0003936976,0.0001891363,0.964873,0.01314613,0.001147909,0.001491225,0.00004459619],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953904,0.0002447166,0.00178955,0.0001204321,0.00001923917,0.00001979046,0.0007473868,0.0001003147,0.001568221],"genre_scores_gemma":[0.9947843,0.0002380567,0.002365259,0.00007139432,0.000006899884,0.00002938633,0.001945704,0.00004445603,0.0005145006],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008396695,"threshold_uncertainty_score":0.01669562,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03088518821628682,"score_gpt":0.3085721851082739,"score_spread":0.2776869968919871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}