{"id":"W4307250618","doi":"10.1007/s40265-022-01797-x","title":"Efficacy and Safety of RBX2660 in PUNCH CD3, a Phase III, Randomized, Double-Blind, Placebo-Controlled Trial with a Bayesian Primary Analysis for the Prevention of Recurrent Clostridioides difficile Infection","year":2022,"lang":"en","type":"article","venue":"Drugs","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":269,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Victoria","funders":"National Center for Advancing Translational Sciences","keywords":"Medicine; Placebo; Clinical endpoint; Internal medicine; Adverse effect; Diarrhea; Randomized controlled trial; Intention-to-treat analysis; Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003245809,0.0002535381,0.001830528,0.0007653692,0.0002071125,0.00002093278,0.0001361452,0.00008372917,0.000154624],"category_scores_gemma":[0.0003155154,0.0001661494,0.0006868658,0.00157033,0.0002098171,0.00005887763,0.0001154494,0.0004179321,2.740798e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002568904,"about_ca_system_score_gemma":0.0004548043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004916401,"about_ca_topic_score_gemma":0.0001186874,"domain_scores_codex":[0.9967596,0.0004697643,0.001199845,0.0004282482,0.0008131005,0.0003294622],"domain_scores_gemma":[0.9966998,0.002000255,0.0005749461,0.0004208116,0.0002031099,0.0001010883],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9806381,0.003369657,0.0001327296,0.0001787022,0.002389217,0.00000353962,0.0009323022,0.001080116,0.001527725,0.00007415657,0.00005129744,0.009622429],"study_design_scores_gemma":[0.9789376,0.00370865,0.0000848083,0.00008645924,0.004122636,0.000007074088,0.0004826423,0.007403383,0.004794841,0.00001581014,0.0002044687,0.0001516694],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9799342,0.0009486935,0.001707853,0.000412362,0.0001060287,0.01642329,0.00006282686,0.00002078368,0.0003839479],"genre_scores_gemma":[0.9952036,0.0005074998,0.00005889399,0.00001313544,0.000120933,0.003485236,0.0002715461,0.00002453911,0.000314689],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01526931,"threshold_uncertainty_score":0.6775374,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02604854827632036,"score_gpt":0.3277597497286944,"score_spread":0.301711201452374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}