{"id":"W4307250618","doi":"10.1007/s40265-022-01797-x","title":"Efficacy and Safety of RBX2660 in PUNCH CD3, a Phase III, Randomized, Double-Blind, Placebo-Controlled Trial with a Bayesian Primary Analysis for the Prevention of Recurrent Clostridioides difficile Infection","year":2022,"lang":"en","type":"article","venue":"Drugs","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":269,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Victoria","funders":"National Center for Advancing Translational Sciences","keywords":"Medicine; Placebo; Clinical endpoint; Internal medicine; Adverse effect; Diarrhea; Randomized controlled trial; Intention-to-treat analysis; Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002462207,0.001398271,0.002876213,0.0004531902,0.0004679599,0.000947679,0.0008551669,0.002021502,0.003220213],"category_scores_gemma":[0.0020656,0.0006256764,0.001864569,0.0003417067,0.001137559,0.0007343937,0.0003491562,0.00227419,0.0006434129],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005830906,"about_ca_system_score_gemma":0.001411626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009381268,"about_ca_topic_score_gemma":0.001884594,"domain_scores_codex":[0.9989884,0.0005735911,0.00006726068,0.0001404016,0.0001051846,0.0001250967],"domain_scores_gemma":[0.9990977,0.0002746448,0.0002313818,0.00006034377,0.00007968972,0.000256268],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9627635,0.009679,0.0004938992,0.0007400925,0.0006128708,0.00002798821,0.00004115263,0.000632961,0.005349251,0.0001167718,0.0005179901,0.0190245],"study_design_scores_gemma":[0.8721483,0.1232362,0.001799063,0.00005437481,0.0004466861,0.00002967142,0.00001531406,0.0009751374,0.0008355991,0.0000913532,0.000347914,0.00002035888],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913552,0.00359045,0.0008727366,0.0004428476,0.0002278314,0.001658789,0.0005516506,0.0001513593,0.001149045],"genre_scores_gemma":[0.9910836,0.002139278,0.001852367,0.0007555417,0.0002532107,0.002080763,0.0005811554,0.00002834775,0.001225607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003220213,"threshold_uncertainty_score":0.01302153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02604854827632036,"score_gpt":0.3277597497286944,"score_spread":0.301711201452374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}