{"id":"W4307252194","doi":"10.1101/2022.10.19.512981","title":"Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neurobiology and Insect Physiology Research","field":"Neuroscience","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Downregulation and upregulation; Lactate dehydrogenase; Biology; Metabolism; Neuron; Cell biology; Citric acid cycle; Neuroscience; Biochemistry; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008171157,0.0003688051,0.000150447,0.0003009381,0.0001811991,0.0003096393,0.0002354997,0.0003049306,0.001373483],"category_scores_gemma":[0.00006975001,0.0001576771,0.0002925029,0.0001303092,0.0002243347,0.0001882594,0.0002621626,0.0004999066,0.000218538],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004787532,"about_ca_system_score_gemma":0.0001521858,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002419027,"about_ca_topic_score_gemma":0.004037531,"domain_scores_codex":[0.9998956,0.00001004862,0.00001912353,0.00003461086,0.00002282961,0.0000178134],"domain_scores_gemma":[0.9998339,0.00001927321,0.00007345433,0.00001486126,0.00001929208,0.00003917583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006232633,0.000009757794,0.0003250779,0.00001722014,0.000005451153,0.00002801966,0.0000184299,0.00003464503,0.9989353,0.00003652056,0.00001811658,0.0005090863],"study_design_scores_gemma":[0.00001934002,0.0002168206,0.0178928,0.00001233855,0.00004614353,0.0001259751,0.0001066588,0.0009219127,0.9786332,0.00005225532,0.001959888,0.000012565],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957203,0.0006083114,0.001765066,0.0000755837,0.0000230475,0.00002326636,0.0009446607,0.00007227284,0.0007674692],"genre_scores_gemma":[0.9915924,0.000513297,0.002579764,0.00009512751,0.000005660285,0.0000536031,0.0007588635,0.00004904376,0.004352207],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002419027,"threshold_uncertainty_score":0.004809976,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03950524903516083,"score_gpt":0.2728840311644999,"score_spread":0.233378782129339,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}