{"id":"W4307256770","doi":"10.26434/chemrxiv-2022-dhq8q","title":"Synthesis of Uronic Acid 1-Azasugars as Putative Inhibitors of a-Iduronidase, b-Glucuronidase and Heparanase","year":2022,"lang":"en","type":"preprint","venue":"ChemRxiv","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Australian Research Council; University of Queensland; Royal Society","keywords":"Heparanase; Chemistry; Glucuronic acid; Iduronic acid; Glucuronidase; Uronic acid; Biochemistry; Stereochemistry; Enantiomer; Glucuronidation; Glycosaminoglycan; Enzyme; Heparan sulfate","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000168249,0.0004689542,0.0004258348,0.0002268357,0.0001355305,0.0002528136,0.0004034436,0.000287676,0.001016811],"category_scores_gemma":[0.000143045,0.000182397,0.0002885853,0.0001910189,0.0001261639,0.0001763247,0.000166958,0.0003909242,0.0004727152],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000306,"about_ca_system_score_gemma":0.000276229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005076088,"about_ca_topic_score_gemma":0.000725156,"domain_scores_codex":[0.9998728,0.00003157499,0.00001449739,0.00002553718,0.00002374629,0.00003177466],"domain_scores_gemma":[0.9999205,0.000009546179,0.0000223057,0.00001028799,0.0000125658,0.00002483014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002512877,0.0000786832,0.00009002973,0.00009477248,0.00002869926,0.0001329854,0.00003046443,0.0007724013,0.9925283,0.000623091,0.0001150628,0.005254123],"study_design_scores_gemma":[0.00008002064,0.0008289882,0.0003691735,0.000008086933,0.00002915907,0.0001562815,0.00001156957,0.0008028348,0.9926683,0.00007805538,0.004956442,0.00001115318],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9743424,0.005804865,0.01164155,0.0001631305,0.0001264125,0.0002687783,0.001119555,0.0002052727,0.006328003],"genre_scores_gemma":[0.9817033,0.003371901,0.009817074,0.00005944498,0.00002347251,0.0000888728,0.0009056293,0.00004110826,0.003989136],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001016811,"threshold_uncertainty_score":0.003401637,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01227796558111306,"score_gpt":0.2429389084905278,"score_spread":0.2306609429094148,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}