{"id":"W4307259124","doi":"10.3410/f.742281114.793595653","title":"Faculty Opinions recommendation of Endosome maturation links PI3Kα signaling to lysosome repopulation during basal autophagy.","year":2022,"lang":"en","type":"dataset","venue":"Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Autophagy; Lysosome; Endosome; PI3K/AKT/mTOR pathway; Basal (medicine); Cell biology; Repopulation; Biology; Signal transduction; Genetics; Biochemistry; Endocrinology; Stem cell; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001327218,0.002354175,0.001536203,0.002533949,0.0008285278,0.002389992,0.002178997,0.002862631,0.03384979],"category_scores_gemma":[0.007160958,0.0005963018,0.002538095,0.003396247,0.0003749865,0.001145814,0.001732262,0.001543861,0.04242636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001492604,"about_ca_system_score_gemma":0.002873946,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.025721,"about_ca_topic_score_gemma":0.06662223,"domain_scores_codex":[0.9986916,0.0002364745,0.0001505997,0.0004468314,0.0002941322,0.0001803369],"domain_scores_gemma":[0.9976209,0.0007382672,0.0003544889,0.0004460591,0.000560154,0.0002801006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004580103,0.00006762366,0.00595664,0.002711985,0.0002636847,0.00006360286,0.0000302945,0.0005875643,0.0005301278,0.0004034629,0.9816711,0.007255922],"study_design_scores_gemma":[0.0008438911,0.00009579205,0.02812345,0.001266957,0.0005126768,0.0003428955,0.0001018642,0.00184539,0.001838714,0.001871106,0.9630668,0.00009048329],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"dataset","genre_gemma":"dataset","genre_scores_codex":[0.000663389,0.0005046268,0.00009689074,0.0001635938,0.00005130653,0.00001517049,0.9972255,0.0002916509,0.0009878305],"genre_scores_gemma":[0.001429254,0.0002276899,0.0003139538,0.0001136513,0.00001186191,0.00004759372,0.9969231,0.00003897437,0.0008937328],"genre_candidate":"dataset","genre_consensus":"dataset","teacher_disagreement_score":0.03384979,"threshold_uncertainty_score":0.1132389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03011868652441274,"score_gpt":0.3582743586667136,"score_spread":0.3281556721423008,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}