{"id":"W4307273988","doi":"10.3390/cancers14215179","title":"Spermidine/Spermine N1-Acetyltransferase 1 (SAT1)—A Potential Gene Target for Selective Sensitization of Glioblastoma Cells Using an Ionizable Lipid Nanoparticle to Deliver siRNA","year":2022,"lang":"en","type":"article","venue":"Cancers","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"CancerCare Manitoba; University of Manitoba","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Spermidine; Spermine; Cell culture; Cell biology; Biochemistry; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008627467,0.0003049658,0.0001975853,0.0001110471,0.00009209202,0.0001701454,0.0001472939,0.0002796897,0.0003688099],"category_scores_gemma":[0.00004466114,0.0001063067,0.0002419884,0.00009703163,0.0001089871,0.0001165653,0.0001496207,0.000257851,0.0001825138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002700316,"about_ca_system_score_gemma":0.0001556356,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008294129,"about_ca_topic_score_gemma":0.001113947,"domain_scores_codex":[0.9999484,0.000005354631,0.000005032389,0.00001710211,0.00001281685,0.00001125035],"domain_scores_gemma":[0.9999789,0.000003312733,0.000007300538,0.000001520418,0.000005004335,0.000003941403],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001587485,0.000004431837,0.00004120277,0.0000272414,0.000002105637,0.00001546186,0.000006233029,0.00003854188,0.9990553,0.00002770751,0.00001925702,0.0007466614],"study_design_scores_gemma":[0.00000316113,0.00008233924,0.0003818346,0.0000014885,0.000008501347,0.000053486,0.000004896862,0.0004547136,0.9980664,0.000006229014,0.0009354061,0.000001679546],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829775,0.002835736,0.01187986,0.0001861997,0.00005452331,0.00006318544,0.0002358895,0.0001495646,0.001617649],"genre_scores_gemma":[0.9878452,0.001642316,0.007198621,0.00008449833,0.0000085603,0.00005901258,0.0003038821,0.00002220612,0.002835651],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008294129,"threshold_uncertainty_score":0.001959264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01160579813015797,"score_gpt":0.245184704284537,"score_spread":0.233578906154379,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}