{"id":"W4307280591","doi":"10.1101/2022.10.23.513420","title":"Junctophilin-2 promotes cardiomyocyte survival by blocking MURF1-mediated Junctin ubiquitination and proteasome-dependentdegradation","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Lawson Health Research Institute; Western University","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Government of Jiangsu Province","keywords":"Cell biology; Internal medicine; Proteasome; Biology; Ubiquitin; Endocrinology; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001120956,0.000640264,0.0004965621,0.0001661093,0.0003044415,0.0002202882,0.000541013,0.0005766948,0.00006124927],"category_scores_gemma":[0.0009586194,0.0007606058,0.0001809254,0.0003029373,0.0001364848,0.00001682371,0.001153248,0.0006794878,0.00001014597],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001872812,"about_ca_system_score_gemma":0.0006126564,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004927417,"about_ca_topic_score_gemma":0.000002405436,"domain_scores_codex":[0.9962706,0.0004329953,0.0005570347,0.00151605,0.0006894307,0.0005338949],"domain_scores_gemma":[0.9975385,0.00005025275,0.0005465019,0.001144065,0.0004339156,0.0002867609],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001002621,0.000151577,0.009081587,0.0003455874,0.000232569,0.00002961195,0.000007772894,0.00007548158,0.9893721,0.00003237679,0.0005637719,0.000007299468],"study_design_scores_gemma":[0.001114286,0.0001703016,0.009209475,0.0001331462,0.0001861484,1.020278e-7,0.00001129244,0.000272265,0.969657,0.000003822989,0.01813566,0.001106471],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991623,0.002997422,0.0009630866,0.0001596157,0.001400095,0.001527278,0.001084254,0.0002316262,0.00001366203],"genre_scores_gemma":[0.9972583,0.0001857335,0.0007722954,0.0001180507,0.0006128413,0.0007592756,0.00006273283,0.0001901933,0.00004057582],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01971507,"threshold_uncertainty_score":0.9994845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0106197070451607,"score_gpt":0.2182832320772572,"score_spread":0.2076635250320965,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}