{"id":"W4307280749","doi":"10.1101/2022.10.23.513379","title":"Antibody avidity and multi-specificity combined to confer protection against SARS-CoV-2 and resilience against viral escape","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Hospital; Health Sciences Centre; Sunnybrook Health Science Centre; University of Toronto; The Scarborough Hospital; Hospital for Sick Children","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Cancer Institute; Canada Research Chairs; National Institutes of Health; Ministry of Colleges and Universities; Hospital for Sick Children; Bill and Melinda Gates Foundation; Sick Kids Foundation; Office of Science; Canadian Institutes of Health Research; Canadian Institute for Advanced Research; Natural Sciences and Engineering Research Council of Canada; Argonne National Laboratory; U.S. Department of Energy","keywords":"Avidity; Monoclonal antibody; Neutralization; Antibody; Virology; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); In vivo; Coronavirus disease 2019 (COVID-19); Potency; Computational biology; Biology; Chemistry; In vitro; Immunology; Medicine; Biochemistry; Genetics; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001960439,0.0004170811,0.0002094165,0.0001624897,0.00009562659,0.0003033587,0.0002407381,0.0003192094,0.001136376],"category_scores_gemma":[0.0001337795,0.0001439416,0.0001968645,0.00007756717,0.0001406603,0.0002335548,0.0003183796,0.0005233301,0.0003257876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002469918,"about_ca_system_score_gemma":0.0001210743,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003937476,"about_ca_topic_score_gemma":0.0005866133,"domain_scores_codex":[0.9998666,0.00001733775,0.000006135862,0.00002389913,0.00003534334,0.0000506554],"domain_scores_gemma":[0.999938,0.000007187882,0.00001649363,0.000008111171,0.00001308118,0.00001709834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003222364,0.00002387313,0.000109997,0.00002138452,0.000006934464,0.0000239382,0.000007891488,0.0002120652,0.9977182,0.0001154171,0.00007200871,0.001656017],"study_design_scores_gemma":[0.00001582944,0.000600311,0.001406393,0.000006282535,0.0000194724,0.0002019447,0.00001189371,0.002337229,0.9912698,0.00006000623,0.004064106,0.000006659942],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988298,0.001387215,0.007327762,0.0001361639,0.00003304875,0.00003698504,0.00009923722,0.0001718795,0.002509628],"genre_scores_gemma":[0.9949278,0.0002970849,0.003302871,0.00008337544,0.00001024073,0.00001731762,0.00009301725,0.00001453318,0.001253832],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001136376,"threshold_uncertainty_score":0.003801525,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04527046447637618,"score_gpt":0.3149700717980214,"score_spread":0.2696996073216452,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}