{"id":"W4307291218","doi":"10.3390/ph15111321","title":"High Efficacy and Drug Synergy of HDAC6-Selective Inhibitor NN-429 in Natural Killer (NK)/T-Cell Lymphoma","year":2022,"lang":"en","type":"article","venue":"Pharmaceuticals","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; National Institutes of Health; Austrian Science Fund; Cancer Research Society","keywords":"Lymphoma; Cancer research; Etoposide; Romidepsin; Medicine; Pharmacology; Biology; Chemotherapy; Immunology; Internal medicine; Histone; Histone deacetylase; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004899669,0.0002118409,0.0002873672,0.0001662873,0.0001360454,0.00001503895,0.0002617501,0.00007996776,0.0001273688],"category_scores_gemma":[0.0001644286,0.0002219587,0.00008315619,0.000349364,0.0002231973,0.000007072964,0.0005581571,0.0003272399,0.000010543],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001233958,"about_ca_system_score_gemma":0.0001826243,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001170774,"about_ca_topic_score_gemma":0.00002214278,"domain_scores_codex":[0.997814,0.000411087,0.0003690745,0.000536676,0.0004020751,0.0004670837],"domain_scores_gemma":[0.9992553,0.0001211822,0.00008702292,0.0002724681,0.00009363282,0.0001703732],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006623561,0.0006963921,0.0002649628,0.00005699344,0.00004747819,0.00003384063,0.0002137818,0.0001392865,0.9813447,0.00006419469,0.01271452,0.003761478],"study_design_scores_gemma":[0.004275899,0.0002438752,0.0003957528,0.00001211325,0.00001720999,0.00002661279,0.0001134684,0.0002203614,0.9351308,0.00001957041,0.05929203,0.000252322],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939553,0.004193546,0.000006665437,0.0003595444,0.0004283944,0.0003719019,0.00003354119,0.00001422081,0.0006368894],"genre_scores_gemma":[0.9968676,0.0002351637,0.0001264566,0.0002361379,0.0001698051,0.00009873154,0.00007035941,0.00004045197,0.002155312],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04657751,"threshold_uncertainty_score":0.9051213,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01188074966228946,"score_gpt":0.3052114178428503,"score_spread":0.2933306681805609,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}