{"id":"W4307291218","doi":"10.3390/ph15111321","title":"High Efficacy and Drug Synergy of HDAC6-Selective Inhibitor NN-429 in Natural Killer (NK)/T-Cell Lymphoma","year":2022,"lang":"en","type":"article","venue":"Pharmaceuticals","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; National Institutes of Health; Austrian Science Fund; Cancer Research Society","keywords":"Lymphoma; Cancer research; Etoposide; Romidepsin; Medicine; Pharmacology; Biology; Chemotherapy; Immunology; Internal medicine; Histone; Histone deacetylase; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007942564,0.0001484926,0.0004228078,0.0001106272,0.00008036671,0.0001599639,0.0001071163,0.0001168187,0.001131033],"category_scores_gemma":[0.00006520968,0.0000639438,0.0001324629,0.0001044487,0.00006776663,0.0001275823,0.0001270837,0.0004042712,0.0003011123],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001269263,"about_ca_system_score_gemma":0.0001681692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004420613,"about_ca_topic_score_gemma":0.001566364,"domain_scores_codex":[0.9999372,0.00001134136,0.000005760103,0.00001602964,0.00001900821,0.00001072965],"domain_scores_gemma":[0.9999725,0.000004949662,0.000004104075,0.000003675528,0.000003969314,0.00001097757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001227857,0.0004326576,0.0005960351,0.0001304547,0.00002631426,0.0001206983,0.0000339636,0.0007824489,0.9661832,0.0001816739,0.0003963446,0.02988831],"study_design_scores_gemma":[0.0002367417,0.0076195,0.006927908,0.00001082548,0.00009338657,0.0006885427,0.0000396228,0.003176227,0.9727769,0.00008352529,0.008332099,0.00001476027],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898465,0.003951417,0.001362223,0.00008052514,0.00005585047,0.00003755092,0.0003070672,0.00006736846,0.004291554],"genre_scores_gemma":[0.9953604,0.001611591,0.0008304693,0.00002877767,0.000009814114,0.00001457971,0.000342387,0.000009720834,0.00179226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001131033,"threshold_uncertainty_score":0.003783643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01188074966228946,"score_gpt":0.3052114178428503,"score_spread":0.2933306681805609,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}