{"id":"W4307296944","doi":"10.1016/j.ijrobp.2022.07.458","title":"Phase III Trial of Dose Escalated Radiation Therapy and Standard Androgen Deprivation Therapy (ADT) vs. Dose Escalated Radiation Therapy and Enhanced ADT with TAK-700 for Men with High-Risk Prostate Cancer (NRG Oncology/RTOG 1115)","year":2022,"lang":"en","type":"article","venue":"International Journal of Radiation Oncology*Biology*Physics","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; BC Cancer Agency","funders":"","keywords":"Medicine; Prostate cancer; Androgen deprivation therapy; Clinical endpoint; Radiation therapy; Urology; Discontinuation; Internal medicine; Oncology; External beam radiotherapy; Randomized controlled trial; Adverse effect; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002621178,0.002545066,0.003306947,0.0006550854,0.0006305345,0.001838973,0.002103383,0.001916281,0.01037972],"category_scores_gemma":[0.001476351,0.0008504316,0.002633231,0.0007269553,0.002272076,0.001547013,0.0006762485,0.006325054,0.001978329],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001809396,"about_ca_system_score_gemma":0.002614505,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00306822,"about_ca_topic_score_gemma":0.005439298,"domain_scores_codex":[0.999297,0.0003018997,0.00002562972,0.0001745002,0.00005078185,0.0001501628],"domain_scores_gemma":[0.9986299,0.0002896396,0.000212244,0.0001504895,0.00005936818,0.0006582985],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9592533,0.01883877,0.000444802,0.000199961,0.0007336719,0.00002164837,0.00008955628,0.001378515,0.002785677,0.0002890804,0.001274495,0.01469049],"study_design_scores_gemma":[0.8734503,0.1218463,0.001702113,0.00001948169,0.0003015941,0.00003109319,0.00004361213,0.0009705056,0.0004838116,0.0003703568,0.0007615273,0.00001920084],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9853725,0.002134172,0.001103381,0.001048729,0.0007958042,0.003022624,0.002344857,0.0002516661,0.003926305],"genre_scores_gemma":[0.9754016,0.001745894,0.003537829,0.00194703,0.0005603143,0.004856954,0.004177155,0.0001064292,0.007666729],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01037972,"threshold_uncertainty_score":0.03472364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02365472668215276,"score_gpt":0.3547738683533663,"score_spread":0.3311191416712135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}