{"id":"W4307303769","doi":"10.1016/j.envint.2022.107603","title":"Exploring oxidative stress and endothelial dysfunction as a mechanism linking bisphenol S exposure to vascular disease in human umbilical vein endothelial cells and a mouse model of postnatal exposure","year":2022,"lang":"en","type":"article","venue":"Environment International","topic":"Effects and risks of endocrine disrupting chemicals","field":"Environmental Science","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"","keywords":"Umbilical vein; Enos; Oxidative stress; Reactive oxygen species; Nitric oxide; Mitochondrion; Mitochondrial ROS; Bioenergetics; Endothelium; Chemistry; Cell biology; Oxidative phosphorylation; Biochemistry; Biology; Endocrinology; Internal medicine; Pharmacology; Nitric oxide synthase; Medicine; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004370333,0.0005686166,0.00029039,0.0006693815,0.0002045424,0.000328223,0.0004048925,0.0007068645,0.001433258],"category_scores_gemma":[0.0001624852,0.0003077481,0.0005300597,0.0004237847,0.0003945384,0.0003652469,0.0002536101,0.001322542,0.00024861],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003425822,"about_ca_system_score_gemma":0.0002379686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005777748,"about_ca_topic_score_gemma":0.0008350585,"domain_scores_codex":[0.99964,0.00005216241,0.00003226783,0.0001083395,0.0001137213,0.0000535211],"domain_scores_gemma":[0.9997373,0.00002157474,0.0001091419,0.00003372448,0.0000401821,0.00005803243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004972779,0.0002165242,0.00149177,0.00009410098,0.00002212892,0.0002490021,0.00005732224,0.00008470861,0.9946253,0.0002512856,0.0001161624,0.002294375],"study_design_scores_gemma":[0.00004558787,0.002386627,0.01962599,0.00003203661,0.0001186821,0.0009092435,0.0001130186,0.001249588,0.9707371,0.000200226,0.00456783,0.0000140898],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9746433,0.003731427,0.01749609,0.0003953875,0.0001584779,0.0001847055,0.001060206,0.0001959333,0.002134461],"genre_scores_gemma":[0.9702311,0.006397979,0.0129251,0.0003041507,0.00004612929,0.0005480595,0.001474501,0.00004861276,0.008024449],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001433258,"threshold_uncertainty_score":0.004794717,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01709686116548163,"score_gpt":0.2562548712297492,"score_spread":0.2391580100642675,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}