{"id":"W4307306496","doi":"10.3180/poster/20221027matthews","title":"Illuminating Dark Proteins using Reactome Pathways","year":2022,"lang":"en","type":"report","venue":"","topic":"Machine Learning in Bioinformatics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"National Institutes of Health","keywords":"Human proteins; Computational biology; Context (archaeology); Druggability; Function (biology); Biology; Gene ontology; Gene; Bioinformatics; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001053283,0.0003820546,0.0003601509,0.0001276165,0.0002480459,0.00005665367,0.0004409877,0.0004566748,0.0006789962],"category_scores_gemma":[0.001054527,0.0003695495,0.0002207894,0.0001378135,0.00006617245,0.000003437653,0.0008665595,0.000740772,0.0000116442],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000201658,"about_ca_system_score_gemma":0.00135957,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000319078,"about_ca_topic_score_gemma":0.00002706736,"domain_scores_codex":[0.9975995,0.00009699191,0.0006010515,0.0004644839,0.0008385081,0.0003994699],"domain_scores_gemma":[0.9981772,0.00001611936,0.0006421802,0.0008146458,0.000256561,0.00009323421],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000142644,0.0006049687,0.01056905,0.0055416,0.001620094,0.0002592315,0.001394185,0.003318849,0.7088819,0.0004277264,0.2142807,0.05295918],"study_design_scores_gemma":[0.0002575068,0.0003428862,0.0001979788,0.0000918792,0.00007676871,0.0005158666,0.0002877465,0.001594699,0.009418528,0.00001778114,0.9863222,0.0008761326],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"other","genre_gemma":"empirical","genre_scores_codex":[0.1045212,0.0007634368,0.003752418,0.00003970733,0.001363347,0.00105823,0.0002155758,0.0001327935,0.8881533],"genre_scores_gemma":[0.5682551,0.002562512,0.2117652,0.001411559,0.007542976,0.0006240968,0.0215881,0.00119387,0.1850565],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.7720416,"threshold_uncertainty_score":0.9998757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0405472090836094,"score_gpt":0.3085624323870138,"score_spread":0.2680152233034043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}