{"id":"W4307306496","doi":"10.3180/poster/20221027matthews","title":"Illuminating Dark Proteins using Reactome Pathways","year":2022,"lang":"en","type":"report","venue":"","topic":"Machine Learning in Bioinformatics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"National Institutes of Health","keywords":"Human proteins; Computational biology; Context (archaeology); Druggability; Function (biology); Biology; Gene ontology; Gene; Bioinformatics; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002114543,0.001802531,0.0006115848,0.006611471,0.0008353975,0.001885988,0.001126723,0.0007275604,0.006511592],"category_scores_gemma":[0.003990795,0.0005286671,0.001827691,0.004197768,0.0005653907,0.002299863,0.002243356,0.001486771,0.001999108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008989923,"about_ca_system_score_gemma":0.0012849,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002881506,"about_ca_topic_score_gemma":0.004121108,"domain_scores_codex":[0.9990355,0.0002594537,0.00007636528,0.0002766518,0.0002732786,0.000078738],"domain_scores_gemma":[0.9977642,0.0009826778,0.0003557892,0.0003893168,0.0003681289,0.0001399215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.003670458,0.0006331542,0.07761731,0.008219546,0.001772141,0.003285397,0.002836856,0.1528972,0.2040942,0.09509242,0.09126218,0.3586191],"study_design_scores_gemma":[0.000224832,0.0002978792,0.02181526,0.000684924,0.0005222486,0.0009663712,0.0009736329,0.4364898,0.1459424,0.1348172,0.2569631,0.000302342],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"other","genre_scores_codex":[0.140109,0.004788309,0.6140729,0.002984276,0.0006196683,0.0004429195,0.1119409,0.1071949,0.01784724],"genre_scores_gemma":[0.3254099,0.005629632,0.5225018,0.001096027,0.0001457662,0.0006969501,0.1333837,0.00582335,0.005312852],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.006611471,"threshold_uncertainty_score":0.02178347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0405472090836094,"score_gpt":0.3085624323870138,"score_spread":0.2680152233034043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}