{"id":"W4307339399","doi":"10.1091/mbc.e22-03-0092","title":"Novel cryo-tomography workflow reveals nanometer-scale responses of epithelial cells to matrix stiffness and dimensionality","year":2022,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Extracellular matrix; Basement membrane; Cell biology; Biology; Electron tomography; Biophysics; Stiffness; Cytoskeleton; Matrix (chemical analysis); Cell; Nanotechnology; Materials science; Biochemistry; Transmission electron microscopy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003646257,0.0005057423,0.0002893928,0.000357186,0.000463105,0.0004373692,0.0005119167,0.0005559585,0.001557495],"category_scores_gemma":[0.000347012,0.0003596737,0.0002855792,0.0002175486,0.0005159493,0.0005402137,0.0005779256,0.001157566,0.000488015],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004434625,"about_ca_system_score_gemma":0.0005187557,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001001903,"about_ca_topic_score_gemma":0.002317915,"domain_scores_codex":[0.9998192,0.00001572419,0.00001683899,0.00006520009,0.00004671894,0.00003631313],"domain_scores_gemma":[0.999635,0.0000813915,0.00006815942,0.00009562226,0.00008059277,0.00003924371],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000204163,0.0000146494,0.0003038173,0.0000279125,0.000004117212,0.0000510505,0.00004044953,0.0005071703,0.9971783,0.0003506333,0.00008529341,0.001416021],"study_design_scores_gemma":[0.000008772188,0.0000894671,0.00593146,0.00001643823,0.00001425429,0.0004081023,0.00007876747,0.01497756,0.9745837,0.0003998009,0.003462583,0.00002892757],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5193844,0.0007158818,0.4708696,0.0005132651,0.0000958285,0.0002503683,0.002097582,0.001710525,0.004362389],"genre_scores_gemma":[0.6327867,0.0009973965,0.3610664,0.0001585588,0.00002950914,0.0004187511,0.001403156,0.0004172951,0.002722298],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001557495,"threshold_uncertainty_score":0.00521034,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007617040654080081,"score_gpt":0.2489315739012229,"score_spread":0.2413145332471429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}