{"id":"W4307340677","doi":"10.1038/s41380-022-01793-3","title":"Uncovering the genetic architecture of broad antisocial behavior through a genome-wide association study meta-analysis","year":2022,"lang":"en","type":"review","venue":"Molecular Psychiatry","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Université du Québec à Montréal; Concordia University; Université de Montréal; Université Laval; Research Unit on Children's Psychosocial Maladjustment","funders":"National Health and Medical Research Council; Horizon 2020 Framework Programme; National Institute of Mental Health; Fonds de Recherche du Québec-Société et Culture; National Institutes of Health; H. Lundbeck A/S; National Institute on Alcohol Abuse and Alcoholism; Suomen Tiedeseura; Signe ja Ane Gyllenbergin Säätiö; Juho Vainion Säätiö; University of Bristol; European Commission; National Institute for Health and Care Research; Medical Research Council; Yrjö Jahnssonin Säätiö; QIMR Berghofer Medical Research Institute; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Wellcome Trust; Lundbeckfonden; National Institute on Drug Abuse; University Hospitals Bristol NHS Foundation Trust; Jalmari ja Rauha Ahokkaan Säätiö","keywords":"Genetic architecture; Heritability; Antisocial personality disorder; Genome-wide association study; Psychology; Genetics; Pleiotropy; Aggression; Psychopathy; Genetic correlation; Single-nucleotide polymorphism; Quantitative trait locus; Clinical psychology; Genetic variation; Genotype; Developmental psychology; Biology; Poison control; Medicine; Gene; Personality; Injury prevention; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004367594,0.001575919,0.004348185,0.002139264,0.0001999572,0.001481066,0.001501636,0.001480349,0.001807303],"category_scores_gemma":[0.006168592,0.0005676603,0.00335898,0.003158818,0.0004184415,0.0007398264,0.001036465,0.001996129,0.0003555167],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006528153,"about_ca_system_score_gemma":0.002045141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003379872,"about_ca_topic_score_gemma":0.008175652,"domain_scores_codex":[0.9988111,0.0004660239,0.0001679679,0.0002973691,0.0002030471,0.00005443372],"domain_scores_gemma":[0.9956244,0.003402055,0.0003639887,0.000162561,0.0003515402,0.00009547834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.00140495,0.0001040316,0.02101212,0.06236832,0.07153964,0.0007431904,0.0001127335,0.001184652,0.002437841,0.003199325,0.01744787,0.8184453],"study_design_scores_gemma":[0.001557407,0.001144119,0.1677402,0.05838801,0.3561386,0.006360386,0.0004912442,0.003027783,0.003693398,0.0365837,0.3643639,0.0005112303],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007262685,0.9977423,0.0005961166,0.0005311174,0.0001140414,0.00000749327,0.0001243843,0.00001107315,0.0001472087],"genre_scores_gemma":[0.008444749,0.9883404,0.001716293,0.0006600142,0.0003237609,0.00002680446,0.0002848903,0.000009414844,0.0001936038],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004367594,"threshold_uncertainty_score":0.02309829,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03906489555344413,"score_gpt":0.3315151010264819,"score_spread":0.2924502054730377,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}