{"id":"W4307342464","doi":"10.1128/mbio.01413-22","title":"Antibiotic Acyldepsipeptides Stimulate the <i>Streptomyces</i> Clp-ATPase/ClpP Complex for Accelerated Proteolysis","year":2022,"lang":"en","type":"article","venue":"mBio","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Eberhard Karls Universität Tübingen; Deutsche Forschungsgemeinschaft","keywords":"Proteolysis; Protease; Proteases; AAA proteins; Streptomyces; Biochemistry; ATPase; Biology; Microbiology; Enzyme; Protein degradation; Chemistry; Bacteria; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004208028,0.0002075378,0.0001965191,0.0000363323,0.000689343,0.00006878759,0.0005184468,0.00008390454,0.0003504968],"category_scores_gemma":[0.00006715833,0.0001628629,0.0001934877,0.0001689498,0.00007029605,0.000004049162,0.0002875437,0.0001115084,0.00002496533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002103672,"about_ca_system_score_gemma":0.00006536935,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003111304,"about_ca_topic_score_gemma":0.000009547862,"domain_scores_codex":[0.9985702,0.0001785509,0.0002494973,0.00044694,0.0001992056,0.0003555929],"domain_scores_gemma":[0.99913,0.00004065411,0.0001390423,0.0005532933,0.00007306453,0.00006390551],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001886617,0.00007905396,0.0003457258,0.00002137343,0.0001146624,0.000002750452,0.00004100299,0.0003413585,0.9858057,0.00009287799,0.008034749,0.004932059],"study_design_scores_gemma":[0.0006115303,0.0004318466,0.0003883091,0.00000620137,0.00005673008,0.00001007547,0.0001256002,0.0003882584,0.8094883,0.0002583582,0.1879818,0.0002529434],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907622,0.0009468305,0.003067122,0.001620744,0.0003659657,0.002157349,0.0003180166,0.00007189849,0.0006898735],"genre_scores_gemma":[0.9947045,0.00002819981,0.001484471,0.001120146,0.0002275796,0.0003566961,0.0004488203,0.00004578658,0.001583822],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1799471,"threshold_uncertainty_score":0.6641355,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03640916287438208,"score_gpt":0.2733755769308933,"score_spread":0.2369664140565113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}