{"id":"W4307342464","doi":"10.1128/mbio.01413-22","title":"Antibiotic Acyldepsipeptides Stimulate the <i>Streptomyces</i> Clp-ATPase/ClpP Complex for Accelerated Proteolysis","year":2022,"lang":"en","type":"article","venue":"mBio","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Eberhard Karls Universität Tübingen; Deutsche Forschungsgemeinschaft","keywords":"Proteolysis; Protease; Proteases; AAA proteins; Streptomyces; Biochemistry; ATPase; Biology; Microbiology; Enzyme; Protein degradation; Chemistry; Bacteria; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001342635,0.0003325821,0.0002429633,0.0001139204,0.0001370779,0.0003292484,0.0001107084,0.0002086598,0.003572231],"category_scores_gemma":[0.0001887928,0.0001331728,0.0002034382,0.0001011371,0.0001290048,0.0001481032,0.0002462242,0.0003938788,0.0009397276],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003391236,"about_ca_system_score_gemma":0.0001735268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004541239,"about_ca_topic_score_gemma":0.0009658061,"domain_scores_codex":[0.9998627,0.00002464052,0.00001153788,0.00002281907,0.00003641973,0.00004185254],"domain_scores_gemma":[0.9998928,0.00002436199,0.00002105244,0.000009224729,0.00001258486,0.00003986138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003439331,0.00003066078,0.0001322889,0.00004004304,0.000003970576,0.00005732412,0.000007560627,0.00003715776,0.9982777,0.00008018455,0.0001886962,0.0008004978],"study_design_scores_gemma":[0.00006731421,0.0003896912,0.006652081,0.00000879756,0.000008039858,0.000272633,0.00003646182,0.0009345635,0.9881018,0.00007170277,0.003450176,0.000006820034],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869519,0.003495859,0.002713914,0.0002237495,0.000121424,0.00005329173,0.0006301771,0.0001652403,0.005644466],"genre_scores_gemma":[0.9935732,0.0006127181,0.001672814,0.0001295907,0.00003393072,0.00002681832,0.0008717171,0.00004124163,0.00303795],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003572231,"threshold_uncertainty_score":0.01195031,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03640916287438208,"score_gpt":0.2733755769308933,"score_spread":0.2369664140565113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}