{"id":"W4307362132","doi":"10.1111/liv.15465","title":"A phase 2, open‐label, randomized, multiple‐dose study evaluating Inarigivir in treatment‐naïve patients with chronic hepatitis B","year":2022,"lang":"en","type":"article","venue":"Liver International","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Society of Intestinal Research; University of Calgary; Toronto Liver Centre; North York General Hospital; Toronto General Hospital; University of Toronto","funders":"","keywords":"Placebo; Medicine; HBsAg; Internal medicine; Gastroenterology; Hepatitis B virus; Adverse effect; Hepatitis B; Randomized controlled trial; Lamivudine; Immunology; Virus; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00055613,0.0002463598,0.0006294016,0.0002626553,0.0002412909,0.00005885182,0.0003127904,0.00002501866,0.001603538],"category_scores_gemma":[0.0003652865,0.0001997206,0.00006510878,0.0002379253,0.00008827657,0.0002543511,0.0005227569,0.0002344462,0.00004485242],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00194295,"about_ca_system_score_gemma":0.0002783491,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.02384102,"about_ca_topic_score_gemma":0.02143053,"domain_scores_codex":[0.9973852,0.0004312081,0.000503469,0.0004813759,0.0009330148,0.000265722],"domain_scores_gemma":[0.9988398,0.0003939679,0.0002170163,0.0002529885,0.000223492,0.00007275376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.04530945,0.01602637,0.9127974,0.000009915473,0.0009622785,0.0003311498,0.004579663,0.000108908,0.00002889467,0.00006920963,0.0002226442,0.01955415],"study_design_scores_gemma":[0.7088079,0.01451176,0.2537176,0.00007864654,0.000233454,0.00001441794,0.0002020784,0.02102397,0.00002032013,0.00002844991,0.001123151,0.0002382456],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924832,0.000201481,0.00002848567,0.000215423,0.0003534395,0.004592353,0.0002139966,0.00003850168,0.001873149],"genre_scores_gemma":[0.9942877,0.00007812247,0.0006445884,0.0002252477,0.0001098045,0.002999894,0.000319111,0.00003525517,0.001300255],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6634985,"threshold_uncertainty_score":0.9993091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06352415516912682,"score_gpt":0.3793821792646608,"score_spread":0.315858024095534,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}