{"id":"W4307366337","doi":"10.1038/s41598-022-23013-2","title":"Development of lipid nanoparticles and liposomes reference materials (II): cytotoxic profiles","year":2022,"lang":"en","type":"article","venue":"Scientific Reports","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"National Research Council Canada; Government of Canada","keywords":"Liposome; Cytotoxic T cell; Nanoparticle; Chemistry; Nanotechnology; Materials science; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001358354,0.0005658501,0.0002792104,0.000838903,0.0002460137,0.0004432309,0.0005611043,0.0006616202,0.001156663],"category_scores_gemma":[0.001701591,0.000234051,0.0002750643,0.0004030958,0.000359221,0.0003586058,0.0003300401,0.0004701658,0.0006766281],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005759142,"about_ca_system_score_gemma":0.0004968974,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005960208,"about_ca_topic_score_gemma":0.0009859148,"domain_scores_codex":[0.999065,0.0002005006,0.0001220643,0.0001504962,0.0004089849,0.00005302189],"domain_scores_gemma":[0.9989692,0.000141928,0.0001897106,0.00008293346,0.0005814686,0.00003477902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001276913,0.0000496459,0.0003656777,0.0003333219,0.00001073173,0.0001094166,0.00008932742,0.000521527,0.9839091,0.0007086779,0.0003365788,0.01343833],"study_design_scores_gemma":[0.000006761582,0.0002133358,0.0002844652,0.00001517911,0.00001073955,0.0001180454,0.00001598105,0.0004195861,0.9944635,0.00004288112,0.004402702,0.000006708829],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7746556,0.01877327,0.186561,0.0006374832,0.0003386736,0.002250911,0.001753524,0.001199275,0.01383033],"genre_scores_gemma":[0.8288752,0.00786663,0.1427029,0.0003983372,0.00006355708,0.002046248,0.003096928,0.0002593689,0.01469095],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001358354,"threshold_uncertainty_score":0.00718379,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01792782518622845,"score_gpt":0.2430476432627217,"score_spread":0.2251198180764933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}