{"id":"W4307392574","doi":"10.1016/j.fertnstert.2022.09.341","title":"UNCOVERING THE MISSING PIECE: COMPREHENSIVE REVIEW OF THE TRANSMISSION OF MITOCHONDRIAL DNA HETEROPLASMY TO THE PREIMPLANTATION EMBRYO","year":2022,"lang":"en","type":"article","venue":"Fertility and Sterility","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"CReATe Fertility Centre","funders":"","keywords":"Heteroplasmy; Mitochondrial DNA; Biology; Genetics; Embryo; Genome; Preimplantation genetic diagnosis; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001576964,0.0007175694,0.001667878,0.002390996,0.0003255938,0.001235361,0.001243331,0.001416825,0.001496776],"category_scores_gemma":[0.0032799,0.000354436,0.0005511871,0.001650376,0.001111107,0.002093143,0.000898143,0.002133622,0.0006619687],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009226873,"about_ca_system_score_gemma":0.001888715,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001427174,"about_ca_topic_score_gemma":0.002792124,"domain_scores_codex":[0.9995444,0.0001083767,0.00009282773,0.00008879301,0.0001314678,0.00003415586],"domain_scores_gemma":[0.9975949,0.001478397,0.0002205139,0.00005870868,0.0005360774,0.0001114046],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0002015364,0.00005640551,0.0006736337,0.02666394,0.0002860517,0.0004958173,0.0002025437,0.0003540236,0.00589498,0.006340817,0.06315202,0.8956782],"study_design_scores_gemma":[0.00002570727,0.0001592529,0.002316324,0.00790604,0.0003988287,0.001843506,0.0002103931,0.0001454887,0.00207943,0.006749206,0.9781095,0.00005629041],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001243141,0.9979082,0.0002433471,0.001180728,0.0003551208,0.000001901504,0.00001458247,0.000005908213,0.0001659223],"genre_scores_gemma":[0.0008550524,0.9968996,0.000261002,0.001080148,0.0006846766,0.000003764875,0.00003039933,0.000002790508,0.0001824343],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002390996,"threshold_uncertainty_score":0.008339882,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01270428714596094,"score_gpt":0.2515146757119907,"score_spread":0.2388103885660297,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}