{"id":"W4307425450","doi":"10.1161/strokeaha.122.040598","title":"Anti-Epileptic Drug Target Perturbation and Intracranial Aneurysm Risk: Mendelian Randomization and Colocalization Study","year":2022,"lang":"en","type":"article","venue":"Stroke","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Thrombosis and Atherosclerosis Research Institute; Population Health Research Institute","funders":"British Heart Foundation; National Institute for Health and Care Research","keywords":"Mendelian randomization; Medicine; Epilepsy; Phenytoin; Pleiotropy; Locus (genetics); Carbamazepine; Internal medicine; Odds ratio; Bioinformatics; Pharmacology; Gene; Genetics; Phenotype; Biology; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01087545,0.001066943,0.001204212,0.00148662,0.0006399357,0.0007167564,0.001324312,0.001190599,0.003679232],"category_scores_gemma":[0.01551729,0.000556232,0.00250583,0.001618875,0.001040376,0.0004291048,0.0007646238,0.0007356545,0.0002425962],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003984929,"about_ca_system_score_gemma":0.0004933602,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002503668,"about_ca_topic_score_gemma":0.001430938,"domain_scores_codex":[0.986259,0.008206527,0.0006198645,0.003348525,0.001088981,0.0004771381],"domain_scores_gemma":[0.9879169,0.006703536,0.002253666,0.002525864,0.0002636101,0.0003364655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0183302,0.0006175629,0.8947817,0.0003221728,0.01324375,0.007207563,0.0007410755,0.00457954,0.02849614,0.006697927,0.001525578,0.0234568],"study_design_scores_gemma":[0.002810351,0.004872184,0.8769121,0.00009097821,0.00937559,0.01629878,0.0004422789,0.07257204,0.006599449,0.006033766,0.003807514,0.0001850115],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9742116,0.0004216626,0.02374625,0.0001849483,0.00003369663,0.0001665171,0.0004492569,0.0001452931,0.0006408388],"genre_scores_gemma":[0.9940335,0.00005734657,0.005350914,0.00004335823,0.00001714515,0.00009424863,0.0001807679,0.00002898982,0.000193589],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01087545,"threshold_uncertainty_score":0.05751556,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004718672758088478,"score_gpt":0.2245703139813241,"score_spread":0.2198516412232356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}