{"id":"W4307426052","doi":"10.7554/elife.78550","title":"Autoantibody discovery across monogenic, acquired, and COVID-19-associated autoimmunity with scalable PhIP-seq","year":2022,"lang":"en","type":"article","venue":"eLife","topic":"Kawasaki Disease and Coronary Complications","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Center for Research Resources; National Institute of Diabetes and Digestive and Kidney Diseases; Leona M. and Harry B. Helmsley Charitable Trust; Institut des maladies génétiques Imagine; Novo Nordisk Fonden; Fondation pour la Recherche Médicale; Parker Institute for Cancer Immunotherapy; Juvenile Diabetes Research Foundation United States of America; National Institute of Allergy and Infectious Diseases; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; American Diabetes Association","keywords":"Autoantibody; Autoimmunity; Immunology; Biology; Disease; Immune dysregulation; Computational biology; Immune system; Antibody; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001029314,0.0007116026,0.0007737793,0.0007396371,0.0007098169,0.001166412,0.0006161985,0.0006335009,0.001126177],"category_scores_gemma":[0.001351809,0.0004074754,0.0008956741,0.0007605553,0.000499425,0.0003540384,0.001515836,0.001203221,0.000525277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000497682,"about_ca_system_score_gemma":0.0005294025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00192818,"about_ca_topic_score_gemma":0.004855249,"domain_scores_codex":[0.9992524,0.000097622,0.00005339804,0.0003555484,0.0001563261,0.00008477664],"domain_scores_gemma":[0.9993708,0.0001995877,0.0000813672,0.000122194,0.0001341367,0.00009200954],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00132234,0.0002684915,0.08569919,0.0009244019,0.001243178,0.0009533831,0.0004821655,0.02142957,0.8405321,0.001938119,0.009037135,0.03616992],"study_design_scores_gemma":[0.0003584456,0.0009725621,0.3290123,0.0002604335,0.001037982,0.003321204,0.0009937071,0.2390835,0.3501147,0.01664406,0.05788372,0.0003174077],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8821088,0.002392618,0.07138224,0.0005011969,0.0001977667,0.0002107542,0.03734492,0.002160145,0.003701439],"genre_scores_gemma":[0.8130047,0.001285601,0.1074446,0.001493545,0.0001203092,0.0005059731,0.07353909,0.0008408789,0.001765338],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00192818,"threshold_uncertainty_score":0.005443573,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02699261355374732,"score_gpt":0.3170074978485034,"score_spread":0.2900148842947561,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}