{"id":"W4307426052","doi":"10.7554/elife.78550","title":"Autoantibody discovery across monogenic, acquired, and COVID-19-associated autoimmunity with scalable PhIP-seq","year":2022,"lang":"en","type":"article","venue":"eLife","topic":"Kawasaki Disease and Coronary Complications","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Center for Research Resources; National Institute of Diabetes and Digestive and Kidney Diseases; Leona M. and Harry B. Helmsley Charitable Trust; Institut des maladies génétiques Imagine; Novo Nordisk Fonden; Fondation pour la Recherche Médicale; Parker Institute for Cancer Immunotherapy; Juvenile Diabetes Research Foundation United States of America; National Institute of Allergy and Infectious Diseases; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; American Diabetes Association","keywords":"Autoantibody; Autoimmunity; Immunology; Biology; Disease; Immune dysregulation; Computational biology; Immune system; Antibody; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002987669,0.0001720627,0.0002849803,0.00005582782,0.001123362,0.00006117464,0.0001793531,0.00004231296,0.0004157941],"category_scores_gemma":[0.0001160911,0.0001557489,0.00007843813,0.0004092551,0.0001660601,0.0001945494,0.0003230873,0.0002046769,0.00002479587],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002847617,"about_ca_system_score_gemma":0.0006882711,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004518772,"about_ca_topic_score_gemma":0.00005615232,"domain_scores_codex":[0.9984977,0.0001221168,0.0002249003,0.0003472879,0.0004395474,0.0003685017],"domain_scores_gemma":[0.9988247,0.00009415964,0.0001089588,0.0005462812,0.00006888517,0.0003569985],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003524347,0.004481358,0.9222469,0.0002563641,0.001279992,0.0005943642,0.004495401,0.001426444,0.01789166,0.002540731,0.0382176,0.003044885],"study_design_scores_gemma":[0.004081163,0.000730811,0.9351538,0.00003381589,0.0002624151,0.0002495924,0.002551315,0.002257412,0.000292225,0.0002161906,0.05378956,0.0003816972],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919848,0.001355548,0.000410248,0.004069262,0.00005850284,0.0004529568,0.0003464829,0.0002446341,0.001077513],"genre_scores_gemma":[0.9881561,0.00008604052,0.00007744342,0.005483857,0.00004685914,0.0001810479,0.0004799146,0.00003238755,0.005456327],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01759944,"threshold_uncertainty_score":0.8640106,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02699261355374732,"score_gpt":0.3170074978485034,"score_spread":0.2900148842947561,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}