{"id":"W4307431329","doi":"10.1128/mbio.02730-22","title":"The Trisubstituted Isoxazole MMV688766 Exerts Broad-Spectrum Activity against Drug-Resistant Fungal Pathogens through Inhibition of Lipid Homeostasis","year":2022,"lang":"en","type":"article","venue":"mBio","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; University of Toronto","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Candida albicans; Biology; Mode of action; Candida auris; Antifungal drug; Fungal pathogen; Isoxazole; Microbiology; Drug resistance; Corpus albicans; Fungicide; Fungus; Pathogen; Biochemistry; Antifungal; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007420652,0.0002464245,0.0004862899,0.0000760395,0.0008849861,0.0000302134,0.0001736524,0.00008026348,0.000262959],"category_scores_gemma":[0.0001636188,0.0001926261,0.0003221823,0.0006234842,0.0002919368,0.0001530626,0.0001759855,0.0005060263,0.00001831014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000357141,"about_ca_system_score_gemma":0.0002852148,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001616568,"about_ca_topic_score_gemma":0.0004453766,"domain_scores_codex":[0.9975136,0.0002581248,0.0004770818,0.0004853029,0.0007702688,0.0004956404],"domain_scores_gemma":[0.9985607,0.0001926515,0.0002554735,0.0007639409,0.0001122351,0.0001149814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01218359,0.00284998,0.03746366,0.0004948025,0.0003827651,0.0004484418,0.003525432,0.00005524568,0.8739479,0.002373401,0.03119204,0.03508275],"study_design_scores_gemma":[0.00552599,0.001200287,0.3278899,0.0002193025,0.0003425935,0.0000427104,0.005767132,0.0002010783,0.5350313,0.001058279,0.1218966,0.0008248395],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908769,0.001530397,0.0001309634,0.002319994,0.0003841251,0.000655962,0.0003151916,0.00009352566,0.003692956],"genre_scores_gemma":[0.9974459,0.0006036542,0.0000681394,0.0003031285,0.0001542937,0.00006860861,0.00008730324,0.00003138016,0.001237637],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3389166,"threshold_uncertainty_score":0.7855064,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01674109359704583,"score_gpt":0.2563303467889211,"score_spread":0.2395892531918752,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}