{"id":"W4307431329","doi":"10.1128/mbio.02730-22","title":"The Trisubstituted Isoxazole MMV688766 Exerts Broad-Spectrum Activity against Drug-Resistant Fungal Pathogens through Inhibition of Lipid Homeostasis","year":2022,"lang":"en","type":"article","venue":"mBio","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; University of Toronto","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Candida albicans; Biology; Mode of action; Candida auris; Antifungal drug; Fungal pathogen; Isoxazole; Microbiology; Drug resistance; Corpus albicans; Fungicide; Fungus; Pathogen; Biochemistry; Antifungal; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007577422,0.0002851529,0.0001750195,0.0001893778,0.0001012095,0.00021358,0.0002672519,0.00012102,0.001469888],"category_scores_gemma":[0.00008451628,0.00007490464,0.0001273085,0.0001620821,0.0001218089,0.0001512994,0.0001536639,0.0003959572,0.0004284663],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001457908,"about_ca_system_score_gemma":0.0002114928,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000360423,"about_ca_topic_score_gemma":0.0009121139,"domain_scores_codex":[0.999935,0.00001096097,0.000006144152,0.00001079602,0.00002113073,0.00001593873],"domain_scores_gemma":[0.999961,0.000003982935,0.00001401287,0.000005539595,0.000006087004,0.000009361625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000130065,0.00004512036,0.0002165767,0.0000632779,0.000008095602,0.0000715725,0.0000117733,0.0002457623,0.9906183,0.0002817077,0.0001010449,0.00820679],"study_design_scores_gemma":[0.00002691011,0.0009027647,0.001191916,0.000008083363,0.00001844759,0.0001984748,0.00001559007,0.0004545598,0.9928842,0.0000601877,0.004232612,0.000006299467],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879194,0.002946145,0.003570204,0.0001314011,0.00005477757,0.0000610587,0.0004783231,0.0001252814,0.00471338],"genre_scores_gemma":[0.9909888,0.002080604,0.003056235,0.00007364395,0.00001176646,0.00002307043,0.0005131113,0.00001789345,0.003234918],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001469888,"threshold_uncertainty_score":0.004917264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01674109359704583,"score_gpt":0.2563303467889211,"score_spread":0.2395892531918752,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}