{"id":"W4307440076","doi":"10.1182/blood.2022018248","title":"Molecular Determinants of Clinical Outcomes In a Real-World Diffuse Large B-cell Lymphoma Population","year":2022,"lang":"en","type":"article","venue":"Blood","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Simon Fraser University; BC Cancer Agency; Kelowna General Hospital; Spinal Cord Injury BC; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Diffuse large B-cell lymphoma; Lymphoma; Population; Germinal center; Oncology; Internal medicine; Fluorescence in situ hybridization; Biology; Cancer research; Medicine; B cell; Immunology; Antibody; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002499457,0.0001127718,0.0005035055,0.0001373375,0.00003930273,0.000003806795,0.00006887758,0.0000386964,0.00004540592],"category_scores_gemma":[0.00005865043,0.00009538561,0.0002012324,0.000189534,0.00001261306,0.0000232485,0.0001017319,0.00005328563,0.000006070626],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007042632,"about_ca_system_score_gemma":0.00006883176,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001213686,"about_ca_topic_score_gemma":0.0004644518,"domain_scores_codex":[0.9986109,0.0001098799,0.0005750963,0.0002339137,0.0002808078,0.0001894255],"domain_scores_gemma":[0.9993142,0.0001063315,0.0001706095,0.0003133333,0.00001748032,0.00007807725],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00007638186,0.03941488,0.9571873,0.000028784,0.00005527448,0.0007234638,0.00005935064,0.000001034712,0.00005570177,0.0001075491,0.00002068205,0.002269631],"study_design_scores_gemma":[0.04283171,0.000390697,0.95362,0.00002319644,0.0002221764,0.00001458696,0.00003483772,0.00007107844,0.002471802,0.00003492403,0.0002052408,0.000079714],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983889,0.0001210852,3.511554e-7,0.0000689716,0.00009732658,0.0003270894,0.00003670616,0.0000212415,0.0009383623],"genre_scores_gemma":[0.9991744,0.00004343901,0.0001541286,0.0002111756,0.00001853436,0.00009503799,0.0000452419,0.00001743073,0.0002406727],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04275533,"threshold_uncertainty_score":0.3889712,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02772950040507347,"score_gpt":0.3427468016348526,"score_spread":0.3150173012297791,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}