{"id":"W4307441073","doi":"10.1126/science.abj3510","title":"Spermidine activates mitochondrial trifunctional protein and improves antitumor immunity in mice","year":2022,"lang":"en","type":"article","venue":"Science","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":200,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"","keywords":"Spermidine; CD8; Protein subunit; Mitochondrion; Chemistry; T cell; Biochemistry; Immunotherapy; Molecular biology; Enzyme; Biology; Immune system; Gene; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001916223,0.00005136255,0.00004972678,0.00005388995,0.0002685517,0.00001973602,0.0002035467,0.0000124719,0.00001445267],"category_scores_gemma":[0.00008164674,0.00004921671,0.00001331384,0.000286574,0.0002146508,0.000008340573,0.0002533829,0.00007742225,0.000001118316],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009461242,"about_ca_system_score_gemma":0.0001352262,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000484546,"about_ca_topic_score_gemma":0.000007303691,"domain_scores_codex":[0.9994209,0.00002353945,0.00007637988,0.0002265749,0.0001170086,0.000135567],"domain_scores_gemma":[0.9997733,0.000004570005,0.00003008451,0.000136637,0.00001975598,0.00003561858],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002530354,0.00004058083,0.0002163967,0.000001458675,8.389498e-7,2.492388e-7,0.00001740508,0.000005096672,0.9984754,0.0002944022,0.00002836154,0.0008944916],"study_design_scores_gemma":[0.0002909258,0.00006923435,0.02228469,0.000001101353,0.00000145846,0.00001009669,0.0001404895,0.00005710664,0.9628644,0.0002717681,0.01393283,0.00007591258],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989157,0.0002466459,0.00007457666,0.000173765,0.0001076954,0.0001819675,0.00002085459,0.00000412498,0.0002746337],"genre_scores_gemma":[0.9985898,0.00001139143,0.0005809943,0.00005035784,0.00008649786,0.00009242831,0.00001576924,0.000003075396,0.0005696983],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03561103,"threshold_uncertainty_score":0.206551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007095506302581394,"score_gpt":0.241917283932541,"score_spread":0.2348217776299596,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}