{"id":"W4307441073","doi":"10.1126/science.abj3510","title":"Spermidine activates mitochondrial trifunctional protein and improves antitumor immunity in mice","year":2022,"lang":"en","type":"article","venue":"Science","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":200,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"","keywords":"Spermidine; CD8; Protein subunit; Mitochondrion; Chemistry; T cell; Biochemistry; Immunotherapy; Molecular biology; Enzyme; Biology; Immune system; Gene; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001651279,0.0005475411,0.000262492,0.0005225472,0.0001025664,0.0002146097,0.0002430993,0.0004399799,0.001268813],"category_scores_gemma":[0.00008250841,0.0001924865,0.0002017776,0.0001846312,0.000229986,0.000233997,0.0001620305,0.000690525,0.0004054576],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002625072,"about_ca_system_score_gemma":0.0001675779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002437687,"about_ca_topic_score_gemma":0.0004543956,"domain_scores_codex":[0.9998617,0.0000248474,0.00001221525,0.0000324763,0.00002908021,0.00003967325],"domain_scores_gemma":[0.9998841,0.000008319864,0.00004339548,0.00001171699,0.00001107827,0.00004135451],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002932716,0.00006700519,0.00007031218,0.00002873632,0.00000406937,0.00001888458,0.000006246759,0.00003824495,0.9977313,0.00008674226,0.00005492723,0.001600389],"study_design_scores_gemma":[0.0001135779,0.002219566,0.002399246,0.00001138804,0.00002245576,0.0001559085,0.00001415447,0.0007303114,0.9912568,0.00007127902,0.002999865,0.000005489287],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929156,0.001804636,0.00233964,0.0002623674,0.00006509451,0.00004328515,0.0004845983,0.0003235667,0.001761227],"genre_scores_gemma":[0.9918576,0.00112096,0.001551844,0.0001117198,0.00002521249,0.00005250567,0.0006313025,0.00004136349,0.004607553],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001268813,"threshold_uncertainty_score":0.004244566,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007095506302581394,"score_gpt":0.241917283932541,"score_spread":0.2348217776299596,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}