{"id":"W4307460411","doi":"10.1016/s0959-8049(22)00845-0","title":"Superior efficacy of a dual EGFR-DNA targeting combi-molecule “ZR2002” in comparison with its analogues 6-mono-alkylamino- and 6,6-dialkylaminoquinazoline in a human osteosarcoma xenograft model","year":2022,"lang":"en","type":"article","venue":"European Journal of Cancer","topic":"Quinazolinone synthesis and applications","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"In vivo; Prodrug; Chemistry; Quinazoline; Pharmacology; Western blot; Epidermal growth factor receptor; Pharmacokinetics; Metabolite; Phosphorylation; Mechanism of action; In vitro; DNA damage; Cancer research; DNA; Receptor; Biochemistry; Biology; Stereochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001095963,0.0002489661,0.0003014806,0.0001345502,0.00006973984,0.0001241248,0.0001962442,0.0002331954,0.001491872],"category_scores_gemma":[0.00006499227,0.00007302405,0.0001446966,0.0001096754,0.0001027619,0.0002157481,0.00006719091,0.0003096841,0.0001690869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000118277,"about_ca_system_score_gemma":0.0001703553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009932895,"about_ca_topic_score_gemma":0.001217995,"domain_scores_codex":[0.9999485,0.00001027128,0.000003587583,0.00001288375,0.00001055156,0.0000141809],"domain_scores_gemma":[0.9999663,0.000005676155,0.000006670182,0.000003472402,0.00000570396,0.00001213707],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009562641,0.0001719946,0.00009045363,0.00006576577,0.00000884045,0.0000293649,0.00001362852,0.0001529256,0.994386,0.00007290723,0.0001703295,0.003881567],"study_design_scores_gemma":[0.0001080791,0.005025734,0.001820102,0.000002913656,0.00004932866,0.0001304169,0.00002142373,0.001226021,0.9891677,0.00002720151,0.002412751,0.000008381032],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967985,0.001111831,0.0007476219,0.00006762425,0.00004190253,0.00001279619,0.0002055248,0.00008677017,0.0009275029],"genre_scores_gemma":[0.9956998,0.0006763519,0.0007347849,0.00002819051,0.00001073735,0.00001673906,0.0003814469,0.00001031187,0.002441729],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001491872,"threshold_uncertainty_score":0.004990816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02085764652218134,"score_gpt":0.2753986134042986,"score_spread":0.2545409668821172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}