{"id":"W4307460411","doi":"10.1016/s0959-8049(22)00845-0","title":"Superior efficacy of a dual EGFR-DNA targeting combi-molecule “ZR2002” in comparison with its analogues 6-mono-alkylamino- and 6,6-dialkylaminoquinazoline in a human osteosarcoma xenograft model","year":2022,"lang":"en","type":"article","venue":"European Journal of Cancer","topic":"Quinazolinone synthesis and applications","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"In vivo; Prodrug; Chemistry; Quinazoline; Pharmacology; Western blot; Epidermal growth factor receptor; Pharmacokinetics; Metabolite; Phosphorylation; Mechanism of action; In vitro; DNA damage; Cancer research; DNA; Receptor; Biochemistry; Biology; Stereochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007406414,0.000226141,0.000562871,0.0002427915,0.0001463659,0.00003451504,0.0003431542,0.00002602276,0.0002063178],"category_scores_gemma":[0.00004066564,0.00021151,0.00009509902,0.0003151206,0.0001132877,0.000108561,0.0001768065,0.0005752937,9.179376e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001286137,"about_ca_system_score_gemma":0.0001185056,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005889594,"about_ca_topic_score_gemma":0.0001285862,"domain_scores_codex":[0.9977426,0.0002076184,0.001039229,0.0002708676,0.000409058,0.0003306386],"domain_scores_gemma":[0.9988007,0.00008560166,0.0006674509,0.0002090642,0.0001227629,0.0001144484],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008920811,0.001814323,0.07373559,0.0002063394,0.0001545534,0.0004849415,0.007041605,0.03395019,0.8714674,0.0003777937,0.0004071209,0.00946808],"study_design_scores_gemma":[0.03772319,0.003245638,0.2942534,0.002454465,0.0006788753,0.000553885,0.01591511,0.04527198,0.5829926,0.0001309047,0.01398507,0.002794905],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940947,0.003555806,0.00004353156,0.0002916481,0.0000203856,0.0001125052,0.00005853195,0.0000118969,0.001810956],"genre_scores_gemma":[0.9991218,0.0001047672,0.0004148537,0.00004240414,0.0001004213,0.00001733302,0.00001595254,0.00005532367,0.0001270748],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2884748,"threshold_uncertainty_score":0.8625127,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02085764652218134,"score_gpt":0.2753986134042986,"score_spread":0.2545409668821172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}