{"id":"W4307493936","doi":"10.1158/2159-8290.cd-22-0523","title":"Cellular Senescence Is Immunogenic and Promotes Antitumor Immunity","year":2022,"lang":"en","type":"letter","venue":"Cancer Discovery","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":325,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Departament d'Empresa i Coneixement, Generalitat de Catalunya; Instituto de Salud Carlos III; Natural Sciences and Engineering Research Council of Canada; Fondation Charles-Bruneau; Centre de recherche du CHU Sainte-Justine; Fonds de Recherche du Québec - Santé; Harald och Greta Jeanssons Stiftelse; Banco Bilbao Vizcaya Argentaria; Vetenskapsrådet; Fundación Científica Asociación Española Contra el Cáncer; Ministerio de Ciencia e Innovación; Generalitat de Catalunya; Cancerfonden; Agència de Gestió d'Ajuts Universitaris i de Recerca; Canadian Institutes of Health Research; Fundación Bancaria Caixa d'Estalvis i Pensions de Barcelona; Fundación BBVA; Karolinska Institutet; Loo och Hans Ostermans Stiftelse för Medicinsk Forskning; Institute for Research in Biomedicine; Institució Catalana de Recerca i Estudis Avançats; Canada Foundation for Innovation","keywords":"Immune system; Senescence; CD8; Cytotoxic T cell; Biology; Antigen presentation; Acquired immune system; Cancer cell; MHC class I; Cell biology; Antigen; Context (archaeology); Cross-presentation; Immunogenic cell death; Immunology; T cell; Cancer; Immunotherapy; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006416729,0.000286516,0.0003576234,0.0002032971,0.0003174821,0.0007330599,0.0001626481,0.003530274,0.002040068],"category_scores_gemma":[0.001396199,0.0001066222,0.0002147876,0.0001114425,0.0006378812,0.0004384015,0.0002926583,0.002255572,0.001411508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006737833,"about_ca_system_score_gemma":0.0002836223,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009907976,"about_ca_topic_score_gemma":0.0002207347,"domain_scores_codex":[0.9995415,0.0001743279,0.0000294101,0.00005172829,0.0001485053,0.00005450148],"domain_scores_gemma":[0.9994282,0.0002893808,0.00008334796,0.00004777369,0.000084534,0.0000665981],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001880705,0.0004115638,0.01204321,0.001344819,0.00008903687,0.058999,0.0006482499,0.0006235454,0.117471,0.05249086,0.4002604,0.3537376],"study_design_scores_gemma":[0.0002323288,0.0008632079,0.008916,0.0002322127,0.00003555427,0.0409909,0.0002044375,0.0009943197,0.01298499,0.01311183,0.9214088,0.00002543245],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.135047,0.1305031,0.008177227,0.561609,0.03654705,0.000266265,0.0002430534,0.0008180854,0.1267893],"genre_scores_gemma":[0.6506681,0.05096205,0.002633012,0.1517599,0.0841793,0.0001607164,0.0001454551,0.00005958555,0.0594319],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.003530274,"threshold_uncertainty_score":0.006824672,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0217868729255454,"score_gpt":0.2629831845038303,"score_spread":0.2411963115782849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}