{"id":"W4307493936","doi":"10.1158/2159-8290.cd-22-0523","title":"Cellular Senescence Is Immunogenic and Promotes Antitumor Immunity","year":2022,"lang":"en","type":"letter","venue":"Cancer Discovery","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":325,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Departament d'Empresa i Coneixement, Generalitat de Catalunya; Instituto de Salud Carlos III; Natural Sciences and Engineering Research Council of Canada; Fondation Charles-Bruneau; Centre de recherche du CHU Sainte-Justine; Fonds de Recherche du Québec - Santé; Harald och Greta Jeanssons Stiftelse; Banco Bilbao Vizcaya Argentaria; Vetenskapsrådet; Fundación Científica Asociación Española Contra el Cáncer; Ministerio de Ciencia e Innovación; Generalitat de Catalunya; Cancerfonden; Agència de Gestió d'Ajuts Universitaris i de Recerca; Canadian Institutes of Health Research; Fundación Bancaria Caixa d'Estalvis i Pensions de Barcelona; Fundación BBVA; Karolinska Institutet; Loo och Hans Ostermans Stiftelse för Medicinsk Forskning; Institute for Research in Biomedicine; Institució Catalana de Recerca i Estudis Avançats; Canada Foundation for Innovation","keywords":"Immune system; Senescence; CD8; Cytotoxic T cell; Biology; Antigen presentation; Acquired immune system; Cancer cell; MHC class I; Cell biology; Antigen; Context (archaeology); Cross-presentation; Immunogenic cell death; Immunology; T cell; Cancer; Immunotherapy; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001872128,0.0006275683,0.0009570837,0.0002373291,0.0003654054,0.0001598993,0.0004328171,0.0004220944,0.002002087],"category_scores_gemma":[0.00004781376,0.0005811608,0.000315011,0.0004057514,0.000401332,0.0003523547,0.0003837854,0.002578583,0.00003214363],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003750702,"about_ca_system_score_gemma":0.0009045764,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001591563,"about_ca_topic_score_gemma":0.00001441855,"domain_scores_codex":[0.9969314,0.0001469924,0.0005033276,0.0009483254,0.0007397335,0.000730174],"domain_scores_gemma":[0.998163,0.0001046981,0.0002946951,0.001211546,0.0001002785,0.0001257485],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003883451,0.0001794911,0.01651642,0.003840164,0.0006863598,0.003524073,0.001338967,7.465394e-7,0.07114872,0.00001340351,0.8986381,0.003725219],"study_design_scores_gemma":[0.001170582,0.000346717,0.007038543,0.001017447,0.0006690962,0.00033358,0.0002495177,0.0000219688,0.02666768,0.00006239832,0.9613678,0.001054615],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.5909688,0.08923743,0.00009543246,0.3118021,0.003135536,0.001872538,0.001703184,0.0002644819,0.0009204007],"genre_scores_gemma":[0.2258338,0.02447301,0.0001455638,0.701992,0.005776168,0.0004917547,0.00193376,0.0003612693,0.03899257],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.3901899,"threshold_uncertainty_score":0.9997225,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0217868729255454,"score_gpt":0.2629831845038303,"score_spread":0.2411963115782849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}