{"id":"W4307494668","doi":"10.1002/ijc.34339","title":"Blood cell DNA methylation biomarkers in preclinical malignant pleural mesothelioma: The EPIC prospective cohort","year":2022,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval","funders":"School of Public Health, Imperial College London; NIHR Imperial Biomedical Research Centre; Instituto de Salud Carlos III; Medical Research Council; Institut Gustave-Roussy; Deutsche Krebshilfe; Vetenskapsrådet; Institut National de la Santé et de la Recherche Médicale; Ministero dell’Istruzione, dell’Università e della Ricerca; Ligue Contre le Cancer; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; Cancer Research UK; Dipartimenti di Eccellenza; Deutsches Krebsforschungszentrum; Cancerfonden; Mutuelle Générale de l'Education Nationale; Associazione Italiana per la Ricerca sul Cancro; Imperial College London; Dartmouth College; World Health Organization","keywords":"European Prospective Investigation into Cancer and Nutrition; Medicine; dNaM; Cohort; Prospective cohort study; Mesothelioma; Oncology; Area under the curve; Biomarker; Internal medicine; DNA methylation; Cancer; EPIC; Receiver operating characteristic; Cohort study; Pathology; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005604422,0.000281376,0.000234159,0.0004013574,0.0003309794,0.0004685067,0.0002508261,0.000334133,0.0008861856],"category_scores_gemma":[0.001008402,0.0002445404,0.0003064493,0.0004456466,0.000179738,0.0001546687,0.0004660988,0.0003479074,0.0002392777],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001246983,"about_ca_system_score_gemma":0.0001686126,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003106835,"about_ca_topic_score_gemma":0.003435154,"domain_scores_codex":[0.9997324,0.00005555488,0.00002049302,0.0001181846,0.00004065129,0.0000326992],"domain_scores_gemma":[0.9995779,0.00005965189,0.00009859943,0.000120942,0.00006247983,0.00008052902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005235074,0.00003517997,0.9911131,0.00001309157,0.0000913346,0.0001633346,0.00008744139,0.0001250296,0.004781638,0.00004355545,0.0001861824,0.002836579],"study_design_scores_gemma":[0.00001142037,0.0001143222,0.9983359,0.00000282887,0.0000590615,0.0003116057,0.00002676764,0.0001909272,0.0004477557,0.0000276841,0.0004694577,0.000002237013],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983369,0.0001832694,0.0003267625,0.00001657493,0.000002920948,0.00001211996,0.0008158521,0.000005656777,0.0002998215],"genre_scores_gemma":[0.9984344,0.00006385714,0.0002468303,0.00001595774,0.000004537311,0.00001461407,0.0009556804,0.000003507902,0.0002606366],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003106835,"threshold_uncertainty_score":0.006177485,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01383486325972092,"score_gpt":0.3094692043325402,"score_spread":0.2956343410728192,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}