{"id":"W4307502328","doi":"10.1016/j.celrep.2022.111537","title":"Phosphorylation of the DNA repair scaffold SLX4 drives folding of the SAP domain and activation of the MUS81-EME1 endonuclease","year":2022,"lang":"en","type":"article","venue":"Cell Reports","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto; University Health Network; Canada Research Chairs; Princess Margaret Cancer Centre; Hospital for Sick Children","funders":"Natural Sciences and Engineering Research Council of Canada; Takeda Canada; Genentech; Canadian Institutes of Health Research; Innovative Medicines Initiative; Ontario Institute for Cancer Research; Kungliga Tekniska Högskolan; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Janssen Pharmaceuticals; Merck KGaA; Princess Margaret Cancer Foundation; European Commission; Pfizer; Genome Canada; Boehringer Ingelheim; Bristol-Myers Squibb","keywords":"Cell biology; Biology; Phosphorylation; Endonuclease; Holliday junction; Nuclease; PLK1; Cyclin-dependent kinase 1; Cell cycle; DNA repair; DNA; Genetics; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001199232,0.0002820346,0.0001135196,0.00009084501,0.0002002016,0.0002656681,0.0001715109,0.0001740726,0.002307788],"category_scores_gemma":[0.0001042776,0.0001294726,0.0001884227,0.00007993494,0.0001916543,0.000289036,0.0003770151,0.0003390182,0.000486573],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003688691,"about_ca_system_score_gemma":0.0001557261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003386498,"about_ca_topic_score_gemma":0.001060406,"domain_scores_codex":[0.9999442,0.000007410709,0.00000338592,0.00001493884,0.0000149489,0.00001522015],"domain_scores_gemma":[0.9999554,0.000009314773,0.00001189554,0.000007600568,0.000004938384,0.00001083926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009259337,0.00001260293,0.0004175401,0.00002485454,0.00000390378,0.00006972199,0.00001298921,0.0001148515,0.997505,0.0003675266,0.00006791022,0.001310468],"study_design_scores_gemma":[0.000009899233,0.00004199023,0.005357232,0.000001569176,0.000002221967,0.0001136592,0.00002007006,0.001203078,0.991778,0.0001137953,0.001354988,0.00000343638],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937212,0.0007162342,0.003031482,0.0001143253,0.00002805534,0.00001098781,0.0001430838,0.00005775047,0.002176845],"genre_scores_gemma":[0.9959557,0.0001941391,0.001592065,0.000022249,0.000003805321,0.000007070223,0.0002585407,0.00001604464,0.001950415],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002307788,"threshold_uncertainty_score":0.007720351,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005201215022629939,"score_gpt":0.1956682040278878,"score_spread":0.1904669890052578,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}