{"id":"W4307548397","doi":"10.3390/pr10112180","title":"Monitoring the Recombinant Adeno-Associated Virus Production using Extended Kalman Filter","year":2022,"lang":"en","type":"article","venue":"Processes","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; McGill University; University of Ottawa","funders":"","keywords":"Extended Kalman filter; Kalman filter; Adeno-associated virus; Titer; Computer science; Recombinant DNA; Production (economics); Vector (molecular biology); Virology; Virus; Biology; Gene; Artificial intelligence; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004580845,0.0005882493,0.0005128412,0.0003597488,0.0001605518,0.0004305827,0.000335848,0.0003613807,0.0003899665],"category_scores_gemma":[0.0008079492,0.0002072785,0.0003900008,0.0002897197,0.0001577539,0.0005419874,0.0002821056,0.0003782241,0.0001600836],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003260004,"about_ca_system_score_gemma":0.0004755777,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006971031,"about_ca_topic_score_gemma":0.005322836,"domain_scores_codex":[0.9997205,0.00003582539,0.0000203736,0.0001047031,0.00009354979,0.00002497611],"domain_scores_gemma":[0.9997277,0.0001023778,0.00005670497,0.00001920522,0.00008635467,0.000007631255],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0003761243,0.0001661171,0.0155724,0.0004733798,0.000177333,0.0001870603,0.0002376289,0.5500205,0.1876923,0.002322658,0.001119653,0.2416548],"study_design_scores_gemma":[0.00001295522,0.00008731896,0.004076122,0.000009926474,0.000027149,0.00003136215,0.00001703065,0.9738748,0.02055342,0.0004184181,0.0008669923,0.0000245384],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.09690785,0.0002988226,0.9005992,0.00006248055,0.00003095287,0.00004443432,0.0002238866,0.0007489591,0.001083443],"genre_scores_gemma":[0.8819914,0.0005050883,0.1155258,0.00003632674,0.0000147467,0.0001237338,0.0004663669,0.00003388078,0.001302691],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.006971031,"threshold_uncertainty_score":0.01386088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02422545920523634,"score_gpt":0.2807345019684819,"score_spread":0.2565090427632455,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}