{"id":"W4307548397","doi":"10.3390/pr10112180","title":"Monitoring the Recombinant Adeno-Associated Virus Production using Extended Kalman Filter","year":2022,"lang":"en","type":"article","venue":"Processes","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; McGill University; University of Ottawa","funders":"","keywords":"Extended Kalman filter; Kalman filter; Adeno-associated virus; Titer; Computer science; Recombinant DNA; Production (economics); Vector (molecular biology); Virology; Virus; Biology; Gene; Artificial intelligence; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001451665,0.0001139529,0.00007876991,0.0000264436,0.0007702632,0.00003824701,0.000181329,0.00003850492,0.00006474622],"category_scores_gemma":[0.0002404545,0.00008875359,0.00005346791,0.0002060339,0.00003279586,0.000007406681,0.0002066617,0.0001154343,0.000002507239],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003535368,"about_ca_system_score_gemma":0.0001069918,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000593535,"about_ca_topic_score_gemma":0.00001353777,"domain_scores_codex":[0.9991118,0.00008918639,0.0001386462,0.0002956599,0.0001677518,0.0001970127],"domain_scores_gemma":[0.9995075,0.000008614932,0.0001130636,0.0002214825,0.000112424,0.00003688536],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001555162,0.0006361954,0.01029051,0.000153659,0.0001155032,0.000005508695,0.0003417164,0.003243929,0.9717889,0.000003780079,0.01072327,0.002541532],"study_design_scores_gemma":[0.0003800119,0.0004597491,0.003268995,0.00004945366,0.00005943194,0.0000526911,0.0006510709,0.00009162984,0.9551091,0.000602697,0.03893169,0.0003434772],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992866,0.005273464,0.00005260594,0.0001305411,0.001303288,0.0001776058,0.00001267106,0.00003207517,0.0001517221],"genre_scores_gemma":[0.9978065,0.0004720959,0.00003514873,0.0001034922,0.0003932283,0.0001509137,0.00002737205,0.00002220315,0.0009890366],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02820842,"threshold_uncertainty_score":0.592432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02422545920523634,"score_gpt":0.2807345019684819,"score_spread":0.2565090427632455,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}