{"id":"W4307551195","doi":"10.3390/pharmaceutics14112297","title":"Pulmonary Safety Profile of Esc Peptides and Esc-Peptide-Loaded Poly(lactide-co-glycolide) Nanoparticles: A Promising Therapeutic Approach for Local Treatment of Lung Infectious Diseases","year":2022,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics","keywords":"Peptide; Nanoparticle; Lung; Medicine; Chemistry; Pharmacology; Internal medicine; Materials science; Nanotechnology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002035768,0.0002293818,0.000189935,0.0001149252,0.00008367059,0.0001830544,0.0001032065,0.0002922929,0.0003645226],"category_scores_gemma":[0.0001707405,0.00006313816,0.0001273994,0.00005473888,0.0001549004,0.0001897067,0.0001098383,0.0002902292,0.0001366474],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009772183,"about_ca_system_score_gemma":0.0001234831,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001284116,"about_ca_topic_score_gemma":0.0001549144,"domain_scores_codex":[0.9998832,0.00002856632,0.00000715989,0.00002491948,0.00004125819,0.00001499114],"domain_scores_gemma":[0.999908,0.00002220855,0.00002663461,0.000008009815,0.00001668178,0.00001854667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001885306,0.00004965754,0.0001878659,0.00006012656,0.000004469251,0.00005310357,0.0000103167,0.0001282095,0.9951748,0.00002131862,0.000025823,0.004095767],"study_design_scores_gemma":[0.00002671807,0.003203448,0.00303673,0.00001012531,0.00002751201,0.0003064123,0.00001870247,0.001152949,0.9904189,0.00003438014,0.001758169,0.000006021782],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990176,0.004896374,0.003963418,0.00008840836,0.00002706499,0.00005411691,0.00008601713,0.00003317771,0.0006754593],"genre_scores_gemma":[0.9954027,0.001787757,0.001848733,0.00008457892,0.00002272647,0.00004063907,0.0001068155,0.00001267396,0.0006933371],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003645226,"threshold_uncertainty_score":0.001219392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02574896892751028,"score_gpt":0.2902291431907118,"score_spread":0.2644801742632015,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}