{"id":"W4307551195","doi":"10.3390/pharmaceutics14112297","title":"Pulmonary Safety Profile of Esc Peptides and Esc-Peptide-Loaded Poly(lactide-co-glycolide) Nanoparticles: A Promising Therapeutic Approach for Local Treatment of Lung Infectious Diseases","year":2022,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics","keywords":"Peptide; Nanoparticle; Lung; Medicine; Chemistry; Pharmacology; Internal medicine; Materials science; Nanotechnology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001633949,0.0002904831,0.000566814,0.0001283369,0.0004794892,0.00001515459,0.0001417808,0.00008517523,0.0001475262],"category_scores_gemma":[0.00001289709,0.0002651999,0.0002095274,0.0001585463,0.0005320282,0.0001349117,0.0001111476,0.0001754597,0.000002069417],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001674316,"about_ca_system_score_gemma":0.0001350366,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009408248,"about_ca_topic_score_gemma":0.000001407749,"domain_scores_codex":[0.9983972,0.0002333154,0.0004925794,0.000363484,0.00007217673,0.0004412882],"domain_scores_gemma":[0.9990788,0.0002755607,0.0003203179,0.0002130548,0.00006278278,0.00004944572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002690639,0.002090179,0.01257473,0.0004278673,0.001069705,0.000006938654,0.001688699,0.0004302086,0.9491616,0.000255891,0.0001717566,0.02943182],"study_design_scores_gemma":[0.004020558,0.001071991,0.001188997,0.00003403896,0.001006114,0.0002752829,0.002895237,0.003461418,0.9822859,0.0001352746,0.003248215,0.0003770033],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.980654,0.01237947,0.002595056,0.00008952285,0.000233799,0.001937875,0.001454705,0.0001016085,0.0005539829],"genre_scores_gemma":[0.9980127,0.000365614,0.0002574118,0.00008635066,0.00003167035,0.0002423874,0.0002580127,0.00004319652,0.0007026403],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03312431,"threshold_uncertainty_score":0.99998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02574896892751028,"score_gpt":0.2902291431907118,"score_spread":0.2644801742632015,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}