{"id":"W4307570293","doi":"10.1016/j.jcmgh.2022.10.014","title":"The Pregnane X Receptor and Indole-3-Propionic Acid Shape the Intestinal Mesenchyme to Restrain Inflammation and Fibrosis","year":2022,"lang":"en","type":"article","venue":"Cellular and Molecular Gastroenterology and Hepatology","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Crohn's and Colitis Canada; Society of Architectural Historians; Canada Research Chairs; U.S. Department of Defense","keywords":"Inflammation; Fibrosis; Pregnane X receptor; Colitis; Biology; Innate immune system; Inflammatory bowel disease; Immunology; Immune system; Medicine; Internal medicine; Nuclear receptor; Biochemistry; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002366224,0.0003888982,0.0002463233,0.000232116,0.0002158813,0.0004903048,0.0003012875,0.0004097176,0.001956571],"category_scores_gemma":[0.0001975574,0.0002461991,0.000388727,0.0001061546,0.0005500669,0.0003757711,0.0005325904,0.0007251971,0.0006301681],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002425444,"about_ca_system_score_gemma":0.0003038476,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004796155,"about_ca_topic_score_gemma":0.0009537076,"domain_scores_codex":[0.9997036,0.00005366414,0.00002108768,0.00004972369,0.0001042539,0.00006767409],"domain_scores_gemma":[0.9998209,0.0000147176,0.0000654449,0.00002058337,0.00002054002,0.00005784526],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001681048,0.000009309683,0.0005230753,0.0001073957,0.000008336174,0.000244035,0.000036543,0.00006980346,0.9954576,0.000702012,0.0001352071,0.002538563],"study_design_scores_gemma":[0.0001207735,0.0008746758,0.02227608,0.00007083593,0.00006670025,0.002438409,0.000379886,0.001294911,0.9460763,0.0007707497,0.02560039,0.00003029094],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9461687,0.02347049,0.01655173,0.001872545,0.000349578,0.00008882838,0.0005133679,0.0004521703,0.01053259],"genre_scores_gemma":[0.9757588,0.006622363,0.006314311,0.0003757913,0.00008783121,0.00005027912,0.0002150571,0.00005759804,0.01051798],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001956571,"threshold_uncertainty_score":0.006545424,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006178151524059278,"score_gpt":0.2077668489596989,"score_spread":0.2015886974356396,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}