{"id":"W4307580626","doi":"10.1007/s00018-022-04568-9","title":"Distinctive aspects of the placental epigenome and theories as to how they arise","year":2022,"lang":"en","type":"review","venue":"Cellular and Molecular Life Sciences","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Fonds de Recherche du Québec - Santé; Fonds de recherche du Québec – Nature et technologies; Canadian Institutes of Health Research; University of California, San Francisco; McGill University","keywords":"Epigenome; Placentation; DNA methylation; Biology; Epigenetics; Epigenesis; Placenta; Genomic imprinting; Somatic cell; CpG site; Methylation; Epigenomics; Cytotrophoblast; Genetics; Evolutionary biology; Gene; Gene expression; Fetus; Pregnancy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007888761,0.0008129349,0.001005519,0.002222224,0.000354569,0.001366197,0.001189001,0.001763588,0.001827764],"category_scores_gemma":[0.0008467396,0.0002813613,0.0003191646,0.00198502,0.002357034,0.002930104,0.001002571,0.003060739,0.001307016],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00117323,"about_ca_system_score_gemma":0.001081692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001070897,"about_ca_topic_score_gemma":0.001391088,"domain_scores_codex":[0.9998376,0.00004135054,0.00001876322,0.00004057555,0.00004125628,0.00002050378],"domain_scores_gemma":[0.9997306,0.0001524913,0.00002804692,0.00001385591,0.00004436878,0.00003067201],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001184511,0.00003116405,0.0003602477,0.01097195,0.00006538974,0.0009874578,0.0003314191,0.0007442159,0.003594266,0.0673527,0.02533351,0.8901092],"study_design_scores_gemma":[0.000007867299,0.00004339793,0.0008242694,0.002017237,0.00003433904,0.002788816,0.0001577655,0.0000829326,0.0006624445,0.01869246,0.97466,0.00002848457],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008461205,0.9972687,0.0003321433,0.0007034714,0.0002343618,0.000002261567,0.00001019487,0.00000503299,0.001359222],"genre_scores_gemma":[0.0008052029,0.9977363,0.00024271,0.0003560008,0.0002699319,0.000005938748,0.00002016845,0.00000153601,0.0005621212],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002222224,"threshold_uncertainty_score":0.008512378,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01948745746815701,"score_gpt":0.2805132894035949,"score_spread":0.2610258319354379,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}