{"id":"W4307590012","doi":"10.1101/2022.10.25.513718","title":"Disrupting peroxisomes alters lipid metabolism in melanoma and uncovers a novel therapeutic vulnerability in combination with MAPK-targeted therapies","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; McGill University Health Centre; McGill University","funders":"Canadian Institutes of Health Research; McGill University; Massachusetts General Hospital","keywords":"Biology; Melanoma; Cancer research; Biogenesis; MAPK/ERK pathway; Cell biology; Signal transduction; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008067631,0.0002862896,0.0002176114,0.0001553688,0.0001032786,0.0002103729,0.0001213529,0.0001945167,0.001178658],"category_scores_gemma":[0.0000423668,0.00008323663,0.0002055254,0.000090871,0.000132628,0.0001376415,0.0001536076,0.000471054,0.0002541944],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002357835,"about_ca_system_score_gemma":0.0001184581,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002637455,"about_ca_topic_score_gemma":0.0005842667,"domain_scores_codex":[0.99994,0.000008387217,0.000004510623,0.00001242009,0.00001797693,0.00001658211],"domain_scores_gemma":[0.9999753,0.000003082814,0.000006981907,0.000004249222,0.000002792298,0.000007619502],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001102275,0.00002330758,0.0001250507,0.00001975805,0.000004169288,0.00002822318,0.0000047056,0.00004062003,0.9979849,0.00003991446,0.00002510981,0.001593963],"study_design_scores_gemma":[0.00001840623,0.0009261651,0.003731242,0.000005086934,0.00002406997,0.0004597644,0.00002173981,0.000592887,0.9915208,0.00005978046,0.002636446,0.000003501714],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994435,0.001980419,0.001791967,0.0001236855,0.00002477807,0.00004070036,0.0002081599,0.0001006659,0.001294585],"genre_scores_gemma":[0.99573,0.001162936,0.0009635912,0.0000384967,0.000005800188,0.00002935209,0.0001991715,0.00001119648,0.001859446],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001178658,"threshold_uncertainty_score":0.003942966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01238476340062667,"score_gpt":0.2260595211383756,"score_spread":0.2136747577377489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}