{"id":"W4307638653","doi":"10.1158/2767-9764.crc-22-0240","title":"<i>Ad hoc</i> Analysis of the Phase III ENGOT-OV16/NOVA Study: Niraparib Efficacy in Germline <i>BRCA</i> Wild-type Recurrent Ovarian Cancer with Homologous Recombination Repair Defects","year":2022,"lang":"en","type":"article","venue":"Cancer Research Communications","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Homologous recombination; Germline; Ovarian cancer; Medicine; Oncology; Biology; Cancer; Genetics; Internal medicine; DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009286215,0.001414844,0.002350231,0.0003936989,0.0002767766,0.001668013,0.0009469327,0.0007461054,0.002529655],"category_scores_gemma":[0.005867007,0.0004213168,0.005130435,0.000565856,0.0007412935,0.0006685663,0.0005425608,0.001675032,0.0004485142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000993688,"about_ca_system_score_gemma":0.001958831,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005937563,"about_ca_topic_score_gemma":0.00162151,"domain_scores_codex":[0.9952074,0.003365871,0.0002057679,0.0005290208,0.0003956455,0.0002963115],"domain_scores_gemma":[0.994991,0.002341789,0.001169923,0.0007100074,0.000355834,0.0004314737],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8243974,0.002781219,0.06726357,0.002240432,0.03242593,0.0003971799,0.0001687936,0.004885207,0.02229793,0.0008258322,0.00714962,0.03516689],"study_design_scores_gemma":[0.3254836,0.2509906,0.291073,0.0003624104,0.04935688,0.00132861,0.0002776485,0.01173286,0.02842868,0.002611845,0.03813806,0.0002157538],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9728888,0.005054037,0.002619321,0.0005775897,0.0002650524,0.003833552,0.00781488,0.0001380733,0.006808738],"genre_scores_gemma":[0.9779027,0.001170445,0.003087837,0.001394336,0.0002895805,0.003615087,0.009357567,0.00009876366,0.003083673],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009286215,"threshold_uncertainty_score":0.04911077,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1542551017670067,"score_gpt":0.4773942007747424,"score_spread":0.3231390990077357,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}