{"id":"W4307642528","doi":"10.1007/s40264-022-01248-2","title":"Characterization of Serous Retinopathy Associated with Cobimetinib: Integrated Safety Analysis of Four Studies","year":2022,"lang":"en","type":"article","venue":"Drug Safety","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"Genentech; F. Hoffmann-La Roche; Roche","keywords":"Medicine; Serous fluid; Retinopathy; Ophthalmology; Internal medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005776659,0.000141802,0.0004306033,0.0001227869,0.0001142417,0.000002751233,0.0001608236,0.00005163454,0.00007643315],"category_scores_gemma":[0.0001465974,0.0001221855,0.0001323125,0.0007759319,0.00007434659,0.000003089322,0.0001485694,0.00009359521,3.968524e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003977355,"about_ca_system_score_gemma":0.00008627484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003422864,"about_ca_topic_score_gemma":0.0001051229,"domain_scores_codex":[0.9986438,0.0003087099,0.0004141937,0.0002656902,0.0002162519,0.000151358],"domain_scores_gemma":[0.9989181,0.0000405388,0.0004283719,0.0002928907,0.000286538,0.00003361254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001026366,0.0001827815,0.02647961,0.00002910028,0.00282523,0.000005429082,0.0009862033,0.0007142087,0.9667926,0.0001038727,0.0001200727,0.0007345094],"study_design_scores_gemma":[0.002563635,0.001493019,0.2935734,0.0000691116,0.002284485,0.00001160036,0.003987934,0.0008883472,0.676257,0.00001699749,0.0182227,0.0006317591],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969976,0.0001066271,0.0005702756,0.00006517427,0.000097773,0.0001763283,0.001597897,0.00001365402,0.0003746926],"genre_scores_gemma":[0.9936745,0.0001198655,0.00008605251,0.00006329193,0.00001796126,0.0000196258,0.005319018,0.00001655209,0.0006831011],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2905356,"threshold_uncertainty_score":0.4982581,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01342398952414582,"score_gpt":0.2281609437359155,"score_spread":0.2147369542117696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}