{"id":"W4307642528","doi":"10.1007/s40264-022-01248-2","title":"Characterization of Serous Retinopathy Associated with Cobimetinib: Integrated Safety Analysis of Four Studies","year":2022,"lang":"en","type":"article","venue":"Drug Safety","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"Genentech; F. Hoffmann-La Roche; Roche","keywords":"Medicine; Serous fluid; Retinopathy; Ophthalmology; Internal medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02813518,0.0008108056,0.001626125,0.00452774,0.0004648859,0.002316507,0.0007570675,0.0007472734,0.001402153],"category_scores_gemma":[0.01799597,0.0002793201,0.00446535,0.003918576,0.0005353515,0.0008169684,0.001179737,0.0006764234,0.0001697103],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001255282,"about_ca_system_score_gemma":0.001621571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006237987,"about_ca_topic_score_gemma":0.001616629,"domain_scores_codex":[0.9858032,0.006265524,0.003375581,0.0009982941,0.003113501,0.0004439336],"domain_scores_gemma":[0.9446278,0.01780547,0.02710611,0.00287547,0.006610869,0.0009743563],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03202992,0.0007897637,0.7304807,0.0102798,0.05479211,0.0003777172,0.0004624491,0.001554659,0.01720818,0.0002245625,0.0009714546,0.1508286],"study_design_scores_gemma":[0.003797301,0.02156253,0.8842254,0.002176011,0.05878721,0.001952948,0.0003311024,0.001520436,0.01324889,0.0004340138,0.01186256,0.0001016405],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9092876,0.07103195,0.005252364,0.0003446369,0.00003914408,0.00267618,0.005775691,0.0001162615,0.005476219],"genre_scores_gemma":[0.9893182,0.004052036,0.002820226,0.0002238372,0.00004721877,0.0006693879,0.002628644,0.00001660117,0.0002238018],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02813518,"threshold_uncertainty_score":0.1487948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01342398952414582,"score_gpt":0.2281609437359155,"score_spread":0.2147369542117696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}