{"id":"W4307643086","doi":"10.1007/978-1-0716-2597-2_9","title":"Microfluidic Chamber Technology to Study Missorting and Spreading of Tau Protein in Alzheimer’s Disease","year":2022,"lang":"en","type":"article","venue":"Methods in molecular biology","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Occupational Cancer Research Centre","funders":"","keywords":"Microtubule; Tau protein; Neuroscience; Microfluidics; Reuptake; Disease; Cell biology; Chemistry; Biology; Biophysics; Alzheimer's disease; Nanotechnology; Biochemistry; Materials science; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002950398,0.0002693276,0.0002052496,0.0002196717,0.0003044696,0.0003809208,0.0003404996,0.0003638101,0.0004879315],"category_scores_gemma":[0.0002438226,0.0001946876,0.0002178194,0.0001905127,0.000166194,0.0003610754,0.0002348519,0.0004221641,0.0001263345],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003735808,"about_ca_system_score_gemma":0.0003467529,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001030756,"about_ca_topic_score_gemma":0.0009779838,"domain_scores_codex":[0.999849,0.0000218504,0.000008833177,0.00004050355,0.00004190476,0.00003789931],"domain_scores_gemma":[0.9998343,0.00007248513,0.00003292798,0.00001465952,0.00002787625,0.0000177667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006483717,0.00003302337,0.0006131843,0.00004376346,0.000008507073,0.00004732599,0.00004280431,0.0003445945,0.9951533,0.0007188555,0.0001614846,0.00276825],"study_design_scores_gemma":[0.0000234989,0.000295088,0.005112641,0.000008026365,0.00003679144,0.0001698126,0.00007322408,0.01871643,0.9712781,0.0003002505,0.003963598,0.00002252278],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.954486,0.005357583,0.03632715,0.0002479689,0.000339812,0.00006901344,0.000359536,0.0001303746,0.002682671],"genre_scores_gemma":[0.968823,0.002733584,0.02494211,0.0001188528,0.00006293149,0.0001510097,0.0002197063,0.00001821635,0.002930584],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001030756,"threshold_uncertainty_score":0.002710581,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04202525252317403,"score_gpt":0.4391027848000624,"score_spread":0.3970775322768884,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}