{"id":"W4307647762","doi":"10.1016/j.actatropica.2022.106732","title":"Leishmania infantum NTPDase1 and NTPDase2 play an important role in infection and nitric oxide production in macrophages","year":2022,"lang":"en","type":"article","venue":"Acta Tropica","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Fundação de Amparo à Pesquisa do Estado de Minas Gerais; Institute of Infection and Immunity; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Canadian Institutes of Health Research; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Natural Sciences and Engineering Research Council of Canada","keywords":"Leishmania infantum; Biology; Macrophage; Amastigote; Nitric oxide; Mutant; Leishmania; Microbiology; Cell biology; Leishmaniasis; Immunology; In vitro; Visceral leishmaniasis; Parasite hosting; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001030689,0.0001031055,0.0001065191,0.0001121713,0.00008851985,0.00001774908,0.0000507674,0.000055202,0.00001738045],"category_scores_gemma":[0.00005345251,0.0001071443,0.00001521896,0.000151895,0.00002737678,0.00001354575,0.0001106682,0.0001489249,2.122126e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001803626,"about_ca_system_score_gemma":0.00002686327,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004828483,"about_ca_topic_score_gemma":0.0001599091,"domain_scores_codex":[0.999188,0.00008161589,0.0001837409,0.000313638,0.00007506163,0.0001579398],"domain_scores_gemma":[0.9997314,0.000006144464,0.00006035455,0.0001445495,0.00001611307,0.00004146822],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00009246449,0.00009375146,0.4562899,0.00001259859,0.000009567942,0.00002078564,0.0001442418,0.00008248902,0.5419741,0.00001714871,0.0006124487,0.0006505002],"study_design_scores_gemma":[0.0008146153,0.0003217561,0.9287216,0.000008455617,0.00001300249,0.0001208453,0.0003214955,0.0002002579,0.05744456,0.0001632174,0.01163217,0.0002380424],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975258,0.002089472,0.0000037738,0.0001187887,0.00006920769,0.000140009,0.000005939026,0.000008991075,0.00003804805],"genre_scores_gemma":[0.9990894,0.0004369215,0.00005897336,0.0000781063,0.0001141786,0.00003980303,0.00006812756,0.00001303968,0.0001014684],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4845295,"threshold_uncertainty_score":0.4369219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004867503448736055,"score_gpt":0.2192989055205597,"score_spread":0.2144314020718236,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}