{"id":"W4307657529","doi":"10.1002/ana.26540","title":"Cell‐Specific Dysregulation of Iron and Oxygen Homeostasis as a Novel Pathophysiology in <scp>PSP</scp>","year":2022,"lang":"en","type":"article","venue":"Annals of Neurology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Brain Institute; University Health Network; Toronto Western Hospital; Occupational Cancer Research Centre; University of Toronto","funders":"Canadian Institutes of Health Research; Parkinson Canada; Edmond J. Safra Philanthropic Foundation","keywords":"Globus pallidus; Neurodegeneration; Progressive supranuclear palsy; Biology; Tauopathy; Homeostasis; Substantia nigra; Pathology; Neuroscience; Neuroinflammation; Pathophysiology; Microglia; Cell biology; Medicine; Immunology; Central nervous system; Inflammation; Endocrinology; Disease; Basal ganglia","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00014023,0.0003933969,0.0002621808,0.0004730769,0.0003241489,0.0002436146,0.0002208686,0.0003908479,0.0007388935],"category_scores_gemma":[0.00008464638,0.0001084528,0.0001623553,0.0002475402,0.0006665514,0.0001757414,0.0002130439,0.0002984748,0.0001359566],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002561327,"about_ca_system_score_gemma":0.0002111859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006430506,"about_ca_topic_score_gemma":0.001140293,"domain_scores_codex":[0.9999275,0.000007052103,0.000004479222,0.00001948932,0.00002450792,0.00001688414],"domain_scores_gemma":[0.9999453,0.000005568194,0.00001961764,0.000005270373,0.000009784572,0.00001447711],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002587841,0.00004091999,0.008676747,0.0001535914,0.00001610365,0.003602698,0.0001198899,0.00008943937,0.9811947,0.0002245786,0.0001743393,0.005448277],"study_design_scores_gemma":[0.00008312517,0.001536084,0.3852402,0.00008034532,0.0001240719,0.02793671,0.0005314626,0.002412054,0.5755487,0.001903318,0.004581655,0.00002221554],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931449,0.002449453,0.002525405,0.0001391663,0.00001717884,0.00003235833,0.0001483066,0.00009839754,0.00144489],"genre_scores_gemma":[0.9960647,0.0009591702,0.001716152,0.00006254518,0.0000324768,0.00003267261,0.0001925537,0.0000062504,0.0009334678],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007388935,"threshold_uncertainty_score":0.002471805,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03487679039624088,"score_gpt":0.2781947440055682,"score_spread":0.2433179536093273,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}