{"id":"W4307701952","doi":"10.3389/fphar.2022.991072","title":"Differentiation and on axon-guidance chip culture of human pluripotent stem cell-derived peripheral cholinergic neurons for airway neurobiology studies","year":2022,"lang":"en","type":"article","venue":"Frontiers in Pharmacology","topic":"Neuroscience and Neural Engineering","field":"Neuroscience","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"ZonMw; Canada Research Chairs; Rijksuniversiteit Groningen","keywords":"Cholinergic; Induced pluripotent stem cell; Neuroscience; Cholinergic neuron; Neurotrophin; Biology; Axon; Cell biology; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000114819,0.000203327,0.0003481,0.0001986556,0.0003361212,0.000009022657,0.0003089189,0.00004174819,0.00001042792],"category_scores_gemma":[0.00002989443,0.0001904443,0.00006836484,0.0002656413,0.0002118409,0.00009176552,0.0001868147,0.0003548854,2.334257e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007558357,"about_ca_system_score_gemma":0.00001572736,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001142299,"about_ca_topic_score_gemma":4.742422e-7,"domain_scores_codex":[0.9982959,0.0002974359,0.0003114537,0.0005878345,0.0001349349,0.0003724537],"domain_scores_gemma":[0.9995281,0.0001116363,0.0001626385,0.000123468,0.00001881324,0.00005534159],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001520398,0.0001353094,0.0004091777,0.00005272735,0.000005316216,0.00001411032,0.0007972457,0.009810829,0.9853468,0.00007833271,0.002917426,0.0002807214],"study_design_scores_gemma":[0.002005024,0.001504405,0.001275318,0.000005988305,0.00002653309,0.00001419282,0.0003490413,0.01384134,0.9789029,0.0001097228,0.001748622,0.0002169322],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935811,0.0003811293,0.0001846976,0.0003169409,0.004834395,0.0005791266,0.00003857226,0.00004525495,0.00003884322],"genre_scores_gemma":[0.9973342,0.0003978907,0.00006958744,0.001432998,0.00007155642,0.0002837027,0.000003429783,0.00002203819,0.0003845831],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006443888,"threshold_uncertainty_score":0.7766094,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03574739742206753,"score_gpt":0.2996159184855295,"score_spread":0.263868521063462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}