{"id":"W4307711163","doi":"10.1186/s40478-022-01456-y","title":"Dual-probe fluorescence spectroscopy for sensitive quantitation of Alzheimer’s amyloid pathology","year":2022,"lang":"en","type":"article","venue":"Acta Neuropathologica Communications","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Health Services; Hotchkiss Brain Institute; University of Calgary","funders":"Alberta Prion Research Institute; Krembil Foundation; Canada Research Chairs","keywords":"Pathology; Amyloid (mycology); Alzheimer's disease; Chemistry; Fluorescence; Immunohistochemistry; Protein aggregation; Biology; Medicine; Disease; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009509093,0.000993386,0.0005199971,0.001329703,0.000489098,0.0005494663,0.0008101669,0.001372496,0.00164098],"category_scores_gemma":[0.0007779989,0.000491889,0.0003315251,0.0005473176,0.0006609865,0.0008748961,0.0008210834,0.001783693,0.0007331137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004646102,"about_ca_system_score_gemma":0.0004064541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004559494,"about_ca_topic_score_gemma":0.0007552498,"domain_scores_codex":[0.9992369,0.0002360264,0.00002278714,0.0002315809,0.0001973945,0.00007534144],"domain_scores_gemma":[0.999558,0.0001824264,0.00006320512,0.00004827552,0.00008474565,0.00006339619],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006206131,0.0000287578,0.0001585007,0.00005359171,0.000006597914,0.00002539095,0.00002591138,0.0001410388,0.9961497,0.0003646391,0.0000966063,0.002887207],"study_design_scores_gemma":[0.00002168823,0.0002628124,0.00225246,0.00001850949,0.0000264302,0.0007272654,0.00004312833,0.01350511,0.979435,0.0007979955,0.002877226,0.00003238302],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.362601,0.004843805,0.625113,0.0004135148,0.0001671082,0.0001867645,0.0005593809,0.001351772,0.004763584],"genre_scores_gemma":[0.6220195,0.003511663,0.3688372,0.0003057379,0.00006493547,0.0005459801,0.0004528644,0.0001358534,0.004126218],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.00164098,"threshold_uncertainty_score":0.005489588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09237071131507996,"score_gpt":0.3675282705529543,"score_spread":0.2751575592378744,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}