{"id":"W4307713717","doi":"10.1208/s12248-022-00762-6","title":"Anti-drug Antibody Sample Testing and Reporting Harmonization","year":2022,"lang":"en","type":"article","venue":"The AAPS Journal","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pfizer (Canada); Canadian Nuclear Laboratories","funders":"Bill and Melinda Gates Foundation","keywords":"Immunogenicity; Harmonization; Computer science; Scope (computer science); Bioanalysis; Sample (material); Medicine; Chemistry; Antibody; Chromatography; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.2590606,0.001136329,0.00200753,0.01096532,0.001976762,0.008867604,0.008354277,0.003214502,0.008280031],"category_scores_gemma":[0.2193169,0.001109639,0.003033744,0.007385714,0.003449628,0.00484335,0.006301271,0.004800438,0.0101701],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003894288,"about_ca_system_score_gemma":0.01746654,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002757924,"about_ca_topic_score_gemma":0.001986302,"domain_scores_codex":[0.6011265,0.2335357,0.04793976,0.01093637,0.1016413,0.004820446],"domain_scores_gemma":[0.6635674,0.0453366,0.02346393,0.09391041,0.1710805,0.002640974],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009128076,0.0007670962,0.008441806,0.004636398,0.0004411554,0.000437926,0.003766258,0.001680913,0.02082268,0.04722122,0.1890515,0.7218202],"study_design_scores_gemma":[0.0001602549,0.000897649,0.01134867,0.001946875,0.0001373667,0.0006514372,0.001046177,0.001893813,0.02483123,0.01159761,0.9453843,0.0001045659],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.02835124,0.01300817,0.664871,0.03362356,0.009209337,0.04406952,0.01267253,0.008849871,0.1853448],"genre_scores_gemma":[0.1627604,0.01117363,0.6971998,0.02364387,0.00351439,0.02890024,0.03068628,0.003577163,0.0385442],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.2590606,"threshold_uncertainty_score":0.9137102,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07532404115153642,"score_gpt":0.3393056505763208,"score_spread":0.2639816094247844,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}