{"id":"W4307715807","doi":"10.1038/s41580-022-00547-x","title":"New insights into activation and function of the AMPK","year":2022,"lang":"en","type":"review","venue":"Nature Reviews Molecular Cell Biology","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":955,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; McMaster University Medical Centre","funders":"Canadian Institutes of Health Research; Cancer Research UK; Wellcome Trust","keywords":"AMPK; AMP-activated protein kinase; Protein kinase A; Energy homeostasis; Adenosine triphosphate; Cell biology; Catabolism; Glycogen; Phosphorylation; Biochemistry; Chemistry; Biology; Metabolism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001728932,0.001819926,0.002106501,0.001916526,0.0003552653,0.002225795,0.001645725,0.002205621,0.002702966],"category_scores_gemma":[0.001255949,0.0006011314,0.000668811,0.002323247,0.001775518,0.00367773,0.001637197,0.005687244,0.002289328],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001310765,"about_ca_system_score_gemma":0.001466533,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000798833,"about_ca_topic_score_gemma":0.001411456,"domain_scores_codex":[0.9996408,0.00005542538,0.00004222818,0.00007452563,0.0001419005,0.00004507874],"domain_scores_gemma":[0.9995141,0.0002352477,0.00004503182,0.00002475075,0.000121599,0.00005924375],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003146852,0.00007959196,0.0001786524,0.01302913,0.0001483826,0.0004022801,0.00007684316,0.00121306,0.008019274,0.03421243,0.06470729,0.8776184],"study_design_scores_gemma":[0.00004853563,0.00006340371,0.0004739697,0.001373571,0.00008009501,0.0005514158,0.0000478968,0.0001537734,0.0009112524,0.01071254,0.985556,0.00002756698],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000052558,0.9978477,0.000226556,0.0006745454,0.0005305682,0.000001692089,0.00001206131,0.00000617816,0.0006481628],"genre_scores_gemma":[0.0004418225,0.9978884,0.0001805802,0.0004850072,0.0005556092,0.000004021615,0.00002551897,0.000001665786,0.0004173633],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002702966,"threshold_uncertainty_score":0.009510338,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01411527989096833,"score_gpt":0.2846837607482887,"score_spread":0.2705684808573204,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}